A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8β-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8β) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8α-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8α) (cf. EC 1.14.14.170 8-epi-inunolide synthase).
The enzyme appears in viruses and cellular organisms
A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8beta) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8alpha-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170 8-epi-inunolide synthase).
the highest level of CYP71BL6 transcript is observed in the leaves with relatively lower expression in the flowers, and much lower levels in the stems and roots
the highest level of CYP71BL6 transcript is observed in the leaves with relatively lower expression in the flowers, and much lower levels in the stems and roots
the highest level of CYP71BL6 transcript is observed in the leaves with relatively lower expression in the flowers, and much lower levels in the stems and roots
the highest level of CYP71BL6 transcript is observed in the leaves with relatively lower expression in the flowers, and much lower levels in the stems and roots
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
coexpression of HaG8H with the enzyme combination HaGAS1 + HaGAO in Nicotiana benthamiana leaves results in the formation of the lactonized version inunolide
Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism
Gou, J.; Hao, F.; Huang, C.; Kwon, M.; Chen, F.; Li, C.; Liu, C.; Ro, D.K.; Tang, H.; Zhang, Y.
Discovery of a non-stereoselective cytochrome P450 catalyzing either 8alpha- or 8beta-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis
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