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EC Tree
IUBMB Comments A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin .
The expected taxonomic range for this enzyme is: Arabidopsis thaliana
Synonyms
cyp82c2,
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CYP82C2
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2 = 4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1].
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8-methoxypsoralen + [reduced NADPH-hemoprotein reductase] + O2
5-hydroxy-8-methoxypsoralen + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
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?
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
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cytochrome P-450
a cytochrome P-450 (heme thiolate) enzyme
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cytochrome P-450
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a cytochrome P-450 (heme thiolate) enzyme
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SwissProt
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highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
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highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
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brenda
highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
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malfunction
reduced resistance to the necrotrophic fungus Botrytis cinerea is caused by a mutation in the cytochrome P450 protein CYP82C2.Overexpression of CYP82C2 is sufficient to increase plant resistance to this pathogen
metabolism
CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis
metabolism
the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
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C82C2_ARATH
523
1
59002
Swiss-Prot
Secretory Pathway (Reliability: 2 )
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highly expressed under a variety of pathogen treatment conditions. Expression is strongly upregulated 24 h after inoculation with the bacterial pathogen Pseudomonas syringae pv. tomato DC3000
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synthesis
the therapeutic compound 8-methoxypsoralen is hydroxylated by plants overexpressing CYP82C2 or CYP82C4, forming 5-hydroxy-8-methoxypsoralen
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Liu, F.; Jiang, H.; Ye, S.; Chen, W.P.; Liang, W.; Xu, Y.; Sun, B.; Sun, J.; Wang, Q.; Cohen, J.D.; Li, C.
The Arabidopsis P450 protein CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis
Cell Res.
20
539-552
2010
Arabidopsis thaliana (O49394)
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Kruse, T.; Ho, K.; Yoo, H.D.; Johnson, T.; Hippely, M.; Park, J.H.; Flavell, R.; Bobzin, S.
In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures
Chem. Biol.
15
149-156
2008
Arabidopsis thaliana (O49394)
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Rajniak, J.; Barco, B.; Clay, N.K.; Sattely, E.S.
A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence
Nature
525
376-379
2015
Arabidopsis thaliana (O49394), Arabidopsis thaliana
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1.14.14.165 indole-3-carbonyl nitrile 4-hydroxylase
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