We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin .
The expected taxonomic range for this enzyme is: Arabidopsis thaliana
Synonyms
At4g31970,
CYP82C2 ,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CYP82C2
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2 = 4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
indole-3-carbonyl nitrile,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1].
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
8-methoxypsoralen + [reduced NADPH-hemoprotein reductase] + O2
5-hydroxy-8-methoxypsoralen + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cytochrome P-450
a cytochrome P-450 (heme thiolate) enzyme
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
SwissProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
-
highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
-
highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
-
-
brenda
-
highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
-
reduced resistance to the necrotrophic fungus Botrytis cinerea is caused by a mutation in the cytochrome P450 protein CYP82C2.Overexpression of CYP82C2 is sufficient to increase plant resistance to this pathogen
metabolism
-
CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis
metabolism
-
the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
C82C2_ARATH
523
1
59002
Swiss-Prot
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
highly expressed under a variety of pathogen treatment conditions. Expression is strongly upregulated 24 h after inoculation with the bacterial pathogen Pseudomonas syringae pv. tomato DC3000
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
synthesis
-
the therapeutic compound 8-methoxypsoralen is hydroxylated by plants overexpressing CYP82C2 or CYP82C4, forming 5-hydroxy-8-methoxypsoralen
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Liu, F.; Jiang, H.; Ye, S.; Chen, W.P.; Liang, W.; Xu, Y.; Sun, B.; Sun, J.; Wang, Q.; Cohen, J.D.; Li, C.
The Arabidopsis P450 protein CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis
Cell Res.
20
539-552
2010
Arabidopsis thaliana (O49394)
brenda
Kruse, T.; Ho, K.; Yoo, H.D.; Johnson, T.; Hippely, M.; Park, J.H.; Flavell, R.; Bobzin, S.
In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures
Chem. Biol.
15
149-156
2008
Arabidopsis thaliana (O49394)
brenda
Rajniak, J.; Barco, B.; Clay, N.K.; Sattely, E.S.
A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence
Nature
525
376-379
2015
Arabidopsis thaliana, Arabidopsis thaliana (O49394)
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
Enzyme Nomenclature
1.14.14.165 indole-3-carbonyl nitrile 4-hydroxylase
top
Information
