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Information on EC 1.14.14.165 - indole-3-carbonyl nitrile 4-hydroxylase for references in articles please use BRENDA:EC1.14.14.165
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IUBMB Comments A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin .
The expected taxonomic range for this enzyme is: Arabidopsis thaliana
Synonyms
At4g31970, CYP82C2,
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CYP82C2
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gene name
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2 = 4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1].
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8-methoxypsoralen + [reduced NADPH-hemoprotein reductase] + O2
5-hydroxy-8-methoxypsoralen + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
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the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
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the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
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cytochrome P-450
a cytochrome P-450 (heme thiolate) enzyme
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SwissProt
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highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
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highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
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highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
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brenda
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highest expression level of CYP82C2 is found in roots, followed by flowers, with relatively low expression in stems and leaves
brenda
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malfunction
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reduced resistance to the necrotrophic fungus Botrytis cinerea is caused by a mutation in the cytochrome P450 protein CYP82C2.Overexpression of CYP82C2 is sufficient to increase plant resistance to this pathogen
metabolism
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CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis
metabolism
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the enzyme is involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense
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C82C2_ARATH
523
1
59002
Swiss-Prot
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highly expressed under a variety of pathogen treatment conditions. Expression is strongly upregulated 24 h after inoculation with the bacterial pathogen Pseudomonas syringae pv. tomato DC3000
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synthesis
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the therapeutic compound 8-methoxypsoralen is hydroxylated by plants overexpressing CYP82C2 or CYP82C4, forming 5-hydroxy-8-methoxypsoralen
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Liu, F.; Jiang, H.; Ye, S.; Chen, W.P.; Liang, W.; Xu, Y.; Sun, B.; Sun, J.; Wang, Q.; Cohen, J.D.; Li, C.
The Arabidopsis P450 protein CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis
Cell Res.
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539-552
2010
Arabidopsis thaliana (O49394)
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Kruse, T.; Ho, K.; Yoo, H.D.; Johnson, T.; Hippely, M.; Park, J.H.; Flavell, R.; Bobzin, S.
In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures
Chem. Biol.
15
149-156
2008
Arabidopsis thaliana (O49394)
brenda
Rajniak, J.; Barco, B.; Clay, N.K.; Sattely, E.S.
A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence
Nature
525
376-379
2015
Arabidopsis thaliana, Arabidopsis thaliana (O49394)
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1.14.14.165 indole-3-carbonyl nitrile 4-hydroxylase
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