Any feedback?
Please rate this page

BRENDA support

show all | hide all No of entries

Information on EC - tryptophan N-monooxygenase

for references in articles please use BRENDA:EC1.14.14.156
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein from the plant Arabidopsis thaliana. This enzyme catalyses two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of both auxin and the indole alkaloid phytoalexin camalexin. The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in viruses and cellular organisms
cyp79b2, cyp79b3, cyp79b1, more
L-tryptophan + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = (E)-indol-3-ylacetaldoxime + 2 [oxidized NADPH-hemoprotein reductase] + CO2 + 3 H2O
show the reaction diagram
overall reaction
L-tryptophan + [reduced NADPH-hemoprotein reductase] + O2 = N-hydroxy-L-tryptophan + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O
show the reaction diagram
N-hydroxy-L-tryptophan + [reduced NADPH-hemoprotein reductase] + O2 = N,N-dihydroxy-L-tryptophan + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
Select items on the left to see more content.