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Information on EC 1.14.14.14 - aromatase

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IUBMB Comments
A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
19-hydroxyandrost-4-ene-3,17-dione + O2 + [reduced NADPH-hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + 2 H2O + [oxidized NADPH-hemoprotein reductase]
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(2b)
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19-hydroxytestosterone + O2 + [reduced NADPH-hemoprotein reductase] = 19-oxotestosterone + 2 H2O + [oxidized NADPH-hemoprotein reductase]
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(1b)
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19-oxoandrost-4-ene-3,17-dione + O2 + [reduced NADPH-hemoprotein reductase] = estrone + formate + H2O + [oxidized NADPH-hemoprotein reductase]
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catalytic reaction mechanism, detailed overview
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19-oxotestosterone + O2 + [reduced NADPH-hemoprotein reductase] = 17beta-estradiol + formate + H2O + [oxidized NADPH-hemoprotein reductase]
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(1c)
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androst-4-ene-3,17-dione + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = estrone + formate + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
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(2)
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androst-4-ene-3,17-dione + O2 + [reduced NADPH-hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H2O + [oxidized NADPH-hemoprotein reductase]
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(2a)
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testosterone + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = 17beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
show the reaction diagram
(1)
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testosterone + O2 + [reduced NADPH-hemoprotein reductase] = 19-hydroxytestosterone + H2O + [oxidized NADPH-hemoprotein reductase]
show the reaction diagram
(1a)
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PATHWAY SOURCE
PATHWAYS
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