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Disease on EC 1.14.14.139 - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase deficiency
Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice.
Carcinoma, Hepatocellular
Disruption of Stard10 gene alters the PPAR?-mediated bile acid homeostasis.
Cholelithiasis
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.
Single nucleotide polymorphism rs3732860 in the 3'-untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese.
Cholestasis
Effects of microplastics (MPs) and tributyltin (TBT) alone and in combination on bile acids and gut microbiota crosstalk in mice.
Cholestasis, Intrahepatic
Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.
cholesterol 7alpha-monooxygenase deficiency
Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.
Colorectal Neoplasms
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
Coronary Thrombosis
New anti-platelet agents: the end of resistance?
Diabetes Mellitus, Type 2
Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment.
Dyslipidemias
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Sterol 12?-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15.
Fatty Liver
Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Gallstones
[Association of single nucleotide polymorphism in human CYP8B1 gene with gallstone disease].
Hyperglycemia
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Hypertension
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Whole rat DNA array survey for candidate genes related to hypertension in kidneys from three spontaneously hypertensive rat substrains at two stages of age and with hypotensive induction caused by hydralazine hydrochloride.
Infections
Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.
Reciprocal regulation of farnesoid X receptor ? activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes.
Insulin Resistance
Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Sterol 12?-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15.
Liver Cirrhosis
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Liver Diseases
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Toxicogenomics directory of chemically exposed human hepatocytes.
Liver Failure
Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene.
Metabolic Diseases
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Metabolic Syndrome
STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS.
Non-alcoholic Fatty Liver Disease
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Obesity
Chemical synthesis of 7-oxygenated 12?-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12?-hydroxylase enzyme implicated in cardiovascular health and obesity.
Chemical synthesis of 7?-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Starvation
Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.