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Information on EC 1.14.14.139 - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase

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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein found in mammals. This is the key enzyme in the biosynthesis of the bile acid cholic acid (3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid . The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent .
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The enzyme appears in viruses and cellular organisms
Synonyms
12-alpha-hydroxylase, 12alpha-hydroxylase CYP8B1, 12alpha-hydroxylase gene, 5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase, CYP8B1, cytochrome P-450 LM4, cytochrome P450 8B1, More, sterol 12alpha hydroxylase, sterol 12alpha-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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