Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB CommentsA cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.
The expected taxonomic range for this enzyme is: Rauvolfia serpentina
Synonyms
deoxysarpagine hydroxylase, more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC 1.14.13.91
-
-
formerly
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MetaCyc
ajmaline and sarpagine biosynthesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10-deoxysarpagine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2
sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2
sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
Products: -
?
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2
sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: most probably the natural substrate
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2
sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: most probably the natural substrate
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ancymidole
-
1.0 mM, 49% inhibition
BAS 110 W
-
1 mM, complete inhibition
BAS 111 W
-
1 mM, 84% inhibition
CO
-
ratio CO:O2 of 9:1, 70% inhibition in the light, 80% inhibition under red light, 77% inhibition under blue light
cytochrome c
-
0.01 mM, 46% inhibition
ketoconazole
-
1 mM, 69% inhibition
LAB 1500978
-
1 mM, 74% inhibition
Metyrapone
-
1 mM, 83% inhibition
NADP+
-
competitive inhibition
Tetcyclacis
-
1 mM, 45% inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0074
10-deoxysarpagine
-
35°C, pH 8.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
associated
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-25°C, 20% sucrose, more than 3 months, no loss of activity
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Yu, B.; Ruppert, M.; Stockigt, J.
Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia
Bioorg. Med. Chem.
10
2479-2483
2002
Rauvolfia serpentina
brenda
html completed
show
top
