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BRENDA support

Information on EC 1.14.14.13 - 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase

for references in articles please use BRENDA:EC1.14.14.13

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IUBMB Comments

Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. FMNH2 is used as a free cofactor. Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase. The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory. Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.

The enzyme appears in viruses and cellular organisms

Synonyms
btrO, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O
show the reaction diagram
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