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EC Tree
IUBMB Comments A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
Word Map
1.14.14.128
molting
epoxidation
larval
silkworm
bombyx
o-methyltransferase
metamorphosis
instar
The expected taxonomic range for this enzyme is: Bombyx mori
Synonyms
cyp15c1, farnesoate epoxidase,
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(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
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(2E,6E)-farnesoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
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(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
-
?
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
-
?
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme exhibits at least 18fold higher activity for farnesoate than (2E,6E)-methyl farnesoate
juvenile-hormone-III carboxylate i.e. (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate
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(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
-
-
?
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
-
-
?
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cytochrome P-450
a heme-thiolate protein
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UniProt
brenda
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the enzyme specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes juvenile hormones. CYP15C1 mRNA is constitutively expressed in corpus allatum from the first instar larval to adult stages, even when juvenile-hormone is not synthesized. No apparent differences in levels of CYP15C1 mRNA are observed between males and females during pupal and adult stages
brenda
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malfunction
CYP15C1 is the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molt. A 68-bp deletion is identified in the mod allele that introduces a premature stop codon in the coding region of CYP15C1
metabolism
the enzyme is involved in the synthesis of juvenile hormone
metabolism
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the enzyme is involved in the synthesis of juvenile hormone
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C15C1_BOMMO
493
0
57206
Swiss-Prot
Secretory Pathway (Reliability: 1 )
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expression in Sf2 or Sf9 cells
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Daimon, T.; Shinoda, T.
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15)
Biotechnol. Appl. Biochem.
60
82-91
2013
Bombyx mori (C0SPF7)
brenda
Daimon, T.; Kozaki, T.; Niwa, R.; Kobayashi, I.; Furuta, K.; Namiki, T.; Uchino, K.; Banno, Y.; Katsuma, S.; Tamura, T.; Mita, K.; Sezutsu, H.; Nakayama, M.; Itoyama, K.; Shimada, T.; Shinoda, T.
Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori
PLoS Genet.
8
e1002486
2012
Bombyx mori (C0SPF7), Bombyx mori
brenda
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1.14.14.128 farnesoate epoxidase
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