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Information on EC 1.14.14.115 - 11-oxo-beta-amyrin 30-oxidase

for references in articles please use BRENDA:EC1.14.14.115

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IUBMB Comments

A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plant Glycyrrhiza uralensis (licorice) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin. The enzyme from the plant Medicago truncatula can also hydroxylate β-amyrin.

The enzyme appears in viruses and cellular organisms

Synonyms
cyp72a, cyp72a154, cyp716a141, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
11-oxo-beta-amyrin + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = glycyrrhetinate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
show the reaction diagram
overall reaction
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11-oxo-beta-amyrin + O2 + [reduced NADPH-hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
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30-hydroxy-11-oxo-beta-amyrin + O2 + [reduced NADPH-hemoprotein reductase] = glycyrrhetaldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
(1b)
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glycyrrhetaldehyde + O2 + [reduced NADPH-hemoprotein reductase] = glycyrrhetinate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1c)
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