Information on EC 1.14.14.1 - unspecific monooxygenase

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EC Tree 1 Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor 1.14.14.1 unspecific monooxygenase

IUBMB Comments

A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH—hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.

The enzyme appears in viruses and cellular organisms

1.14.14.1
cyp3a4
hepatocytes
cyp2c19
drug-drug
epoxide
phenobarbital
dosing
women
smoke
heme
s-transferase
isozymes
cholesterol
hepatotoxicity
smoking
polycyclic
adduct
benzoapyrene
urine
pharmacogenetic
steroidogenic
disposition
androgen
interindividual
pharmacodynamic
gst
warfarin
toxicological
concentration-time
progesterone
p-glycoprotein
caucasian
estradiol
genotoxic
ethnic
antidepressant
steroidogenesis
insecticide
cigarette
caffeine
glucuronidation
coadministration
androstenedione
anticoagulant
trough
coumarins
acetaminophen
biphenyls
tacrolimus
erythromycin
synthesis
biotechnology
medicine
environmental protection
agriculture

Synonyms
p450, cyp2d6, cyp1a1, cyp2e1, cyp1a2, cyp2c9, cyp1b1, cyp3a5, cyp2b6, cyp1a, more