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Enzyme Nomenclature
Information on EC 1.14.13.79 - ent-kaurenoic acid oxidase
for references in articles please use BRENDA:EC1.14.13.79
Word Map on EC 1.14.13.79
- 1.14.13.79
- ent-kaurene
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protoplast-derived
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ent-copalyl
- ga20ox
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petty
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.14.13.79
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RECOMMENDED NAME
GeneOntology No.
ent-kaurenoic acid oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + H+ + O2 = gibberellin A12 aldehyde + NADP+ + 2 H2O
second step, The second step includes a ring-B contraction giving the gibbane skeleton
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ent-kaur-16-en-19-oate + 3 NADPH + 3 H+ + 3 O2 = gibberellin A12 + 3 NADP+ + 4 H2O
overall reaction
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ent-kaur-16-en-19-oate + NADPH + H+ + O2 = ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
first step
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gibberellin A12 aldehyde + NADPH + H+ + O2 = gibberellin A12 + NADP+ + H2O
third step
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating)
Requires cytochrome P-450. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6alpha,7alpha-dihydroxykaur-16-en-19-oate is also formed.
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CAS REGISTRY NUMBER
COMMENTARY
337507-95-6
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Kao fragment (Kao3), Aegilops tauschii; Tausch's goatgrass, diploid
UniProt
dwarf mutant of barley that accumulates ent-keurenoic acid in developing grains
Uniprot
cv. Grand Rapids, gene LsKAO encoding a ent-kaurenoic acid oxidase
UniProt
Kao-A1 fragment, Triticum aestivum cultivar Chinese spring, cultivar Opata 85, and cultivar W7984; bread wheat cultivar Chinese Spring, Opata 85, and the synthetic hexaploid cultivar W7984
UniProt
Kao-A1 fragment, Triticum aestivum cultivar Prinz; bread wheat cultivar Prinz
UniProt
Kao-B1 fragment (Kao2), Triticum aestivum cultivar Opata 85; bread wheat cultivar Opata 85
UniProt
Kao-B1 fragment (Kao2), Triticum aestivum cultivar Prinz; bread wheat cultivar Prinz
UniProt
Kao-B1 fragment (Kao2), Triticum aestivum cultivar W7984; bread wheat synthetic hexaploid cultivar W7984
UniProt
Kao-D1 fragment (Kao3), Triticum aestivum cultivar Chinese spring; bread wheat cultivar Chinese Spring
UniProt
Kao-D1 fragment (Kao3), Triticum aestivum cultivar Opata 85; bread wheat cultivar Opata 85
UniProt
Kao-D1 fragment (Kao3), Triticum aestivum cultivar Prinz; bread wheat cultivar Prinz
UniProt
Kao-D1 fragment (Kao3), Triticum aestivum cultivar W7984; bread wheat synthetic hexaploid cultivar W7984
UniProt
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
metabolism
catalyzes three steps in the gibberellin biosynthesis pathway
metabolism
catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway; catalyzes three steps in the gibberellin biosynthesis pathway
metabolism
catalyzes three steps in the gibberellin biosynthesis pathway
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + H+ + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
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-
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
ent-kaur-16-en-19-oate + NADPH + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
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-
-
-
?
additional information
?
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the enzyme is involved in the biosynthetic pathway and metabolism of gibberellins, gibberellin mediates the control of seed germination by phytochrome mainly via the control of the endogenous content of bioactive gibberellic acid, rather than the control of gibberellic acid responsiveness, gibberellin metabolism and signalling in lettuce seed, overview
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ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
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the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
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-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
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-
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
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-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
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the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
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-
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
gibberellin A12 aldehyde + NADPH + O2
gibberellin A12 + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
gibberellin A12 aldehyde + NADPH + O2
gibberellin A12 + NADP+ + H2O
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
gibberellin A12 aldehyde + NADPH + O2
gibberellin A12 + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + H+ + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
-
-
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
ent-kaur-16-en-19-oate + NADPH + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
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-
-
-
?
additional information
?
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B5MEX7
the enzyme is involved in the biosynthetic pathway and metabolism of gibberellins, gibberellin mediates the control of seed germination by phytochrome mainly via the control of the endogenous content of bioactive gibberellic acid, rather than the control of gibberellic acid responsiveness, gibberellin metabolism and signalling in lettuce seed, overview
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-
-
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
Q9AXH9
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
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-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
-
-
-
-
?
ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + O2
gibberellin A12 aldehyde + NADP+ + 2 H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
C7T4H4
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-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
Q9AXH9
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
-
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
C7T4G2, C7T4G3, C7T4G4, C7T4G6, C7T4G7, C7T4G8, C7T4G9, C7T4H1, C7T4H2
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-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
C7T4H3
-
-
-
?
ent-kaur-16-en-19-oate + NADPH + H+ + O2
ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
gibberellin A12 aldehyde + NADPH + O2
gibberellin A12 + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
gibberellin A12 aldehyde + NADPH + O2
gibberellin A12 + NADP+ + H2O
Q9AXH9
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
gibberellin A12 aldehyde + NADPH + O2
gibberellin A12 + NADP+ + H2O
-
the enzyme catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to gibberellin A12
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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developing, expression of the gene PsKAO1, the gene PsKAO1 is expressed only in seed
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
both genes PsKAO1 and PsKAO2 encode the ent-kaurenoic acid oxidase, expression in Saccharomyces cerevisiae
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expression in yeast
gene LsKAO, DNA and amino acid sequence determination and analysis, quantitative PCR expression analysis, expression in Pichia pastoris
PCR-amplification
PCR-amplification; PCR-amplification; PCR-amplification; PCR-amplification; PCR-amplification; PCR-amplification; PCR-amplification; PCR-amplification; PCR-amplification
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.79)
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