Reference on EC 1.14.13.70 - sterol 14alpha-demethylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Park, J.W.; Byrd, A.; Lee, C.M.; Morgan, E.T.
Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14alpha-demethylase
Biochem. J.
474
3241-3252
2017
Homo sapiens (Q16850)
Manually annotated by BRENDA team
Morrison, A.; Goldstone, J.; Lamb, D.; Kubota, A.; Lemaire, B.; Stegeman, J.
Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14alpha-demethylase
Biochim. Biophys. Acta
1840
1825-1836
2014
Danio rerio
Manually annotated by BRENDA team
Emami, S.; Tavangar, P.; Keighobadi, M.
An overview of azoles targeting sterol 14?-demethylase for antileishmanial therapy
Eur. J. Med. Chem.
135
241-259
2017
Leishmania major, Leishmania mexicana, Leishmania infantum (A2TEF2)
Manually annotated by BRENDA team
Borcea, A.; Marc, G.; Pirnau, A.; Vlase, L.; Ionut, I.; Tiperciuc, B.; Oniga, O.
Synthesis and molecular docking study of some new 1,4-phenylene-bisthiazoles as fungal lanosterol 14alpha-demethylase inhibitors
Farmacia
65
683-689
2017
Candida albicans SC5314 (P10613)
-
Manually annotated by BRENDA team
Stana, A.; Vodnar, D.C.; Tamaian, R.; Pirn?u, A.; Vlase, L.; Ionu?, I.; Oniga, O.; Tiperciuc, B.
Design, synthesis and antifungal activity evaluation of new thiazolin-4-ones as potential lanosterol 14alpha-demethylase inhibitors
Int. J. Mol. Sci.
18
E177
2017
Candida albicans SC5314 (P10613)
Manually annotated by BRENDA team
Hargrove, T.Y.; Friggeri, L.; Wawrzak, Z.; Qi, A.; Hoekstra, W.J.; Schotzinger, R.J.; York, J.D.; Guengerich, F.P.; Lepesheva, G.I.
Structural analyses of Candida albicans sterol 14alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis
J. Biol. Chem.
292
6728-6743
2017
Candida albicans (Q9P4W0)
Manually annotated by BRENDA team
Friggeri, L.; Hargrove, T.Y.; Rachakonda, G.; Williams, A.D.; Wawrzak, Z.; Di Santo, R.; De Vita, D.; Waterman, M.R.; Tortorella, S.; Villalta, F.; Lepesheva, G.I.
Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14alpha-demethylase two regions of the enzyme molecule potentiate its inhibition
J. Med. Chem.
57
6704-6717
2014
Trypanosoma cruzi (Q7Z1V1), Trypanosoma cruzi CL Brener (Q7Z1V1)
Manually annotated by BRENDA team
Alvarez-Rueda, N.; Fleury, A.; Loge, C.; Pagniez, F.; Robert, E.; Morio, F.; Le Pape, P.
The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance
Med. Mycol.
54
764-775
2016
Candida albicans (C8XRD8)
Manually annotated by BRENDA team
Tyndall, J.D.; Sabherwal, M.; Sagatova, A.A.; Keniya, M.V.; Negroni, J.; Wilson, R.K.; Woods, M.A.; Tietjen, K.; Monk, B.C.
Structural and functional elucidation of yeast lanosterol 14alpha-demethylase in complex with agrochemical antifungals
PLoS ONE
11
e0167485
2016
Saccharomyces cerevisiae (A6ZSR0), Saccharomyces cerevisiae YJM789 (A6ZSR0)
Manually annotated by BRENDA team
Warrilow, A.G.; Price, C.L.; Parker, J.E.; Rolley, N.J.; Smyrniotis, C.J.; Hughes, D.D.; Thoss, V.; Nes, W.D.; Kelly, D.E.; Holman, T.R.; Kelly, S.L.
Azole antifungal sensitivity of sterol 14alpha-demethylase (CYP51) and CYP5218 from Malassezia globosa
Sci. Rep.
6
27690
2016
Malassezia globosa (A8Q3I7), Malassezia globosa CBS 7966 (A8Q3I7)
Manually annotated by BRENDA team