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IUBMB Comments Also acts on N -acetyl-leukotriene E4 EC 1.14.14.94 , leukotriene-B4
Synonyms
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leukotriene-E4 omega-hydroxylase
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oxygenase, leukotriene E4 20-mono
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ + H2O
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.14.94, leukotriene-B4 20-monooxygenase.
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
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Substrates: leukotriene E4
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
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Substrates: metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes
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N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
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Substrates: -
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N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
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Substrates: at a rate six times lower than leukotriene E4
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
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Substrates: metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes
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(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
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competitively inhibits leukotriene E4 omega-oxidation
Halothane
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induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme
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0.08
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
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additional information
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male Sprague Dawley rats
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phenobarbital-treated
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the specific activity is about 12times lower than for liver
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the specific activity is about 12times lower than for liver
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highest activity
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Highest Expressing Human Cell Lines
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Orning, L.
omega-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes
Eur. J. Biochem.
170
77-85
1987
Rattus norvegicus
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Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro
Eur. J. Biochem.
206
869-897
1992
Rattus norvegicus
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