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Information on EC 1.14.13.233 - 4-hydroxy-6-methylpretetramide 12a-monooxygenase

for references in articles please use BRENDA:EC1.14.13.233

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IUBMB Comments

Contains FAD. The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. The enzyme is bifunctional, and can also catalyse EC 1.14.13.232, 6-methylpretetramide 4-monooxygenase.

The expected taxonomic range for this enzyme is: Streptomyces rimosus

Synonyms
oxyL, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 = 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
tetracycline and oxytetracycline biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links