Information on EC 1.14.13.19 - taxifolin 8-monooxygenase

for references in articles please use BRENDA:EC1.14.13.19
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The expected taxonomic range for this enzyme is: Pseudomonas sp.

top print hide
EC NUMBER
COMMENTARY hide
1.14.13.19
-
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RECOMMENDED NAME
GeneOntology No.
taxifolin 8-monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O
show the reaction diagram
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercitin or mollisacidin
-
-
-
top print hide
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin.
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CAS REGISTRY NUMBER
COMMENTARY hide
39307-19-2
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-fustin + NADH + O2
? + NAD+ + H2O
show the reaction diagram
-
-
product not identified
?
taxifolin + NADH + O2
2,3-dihydrogossypetin + NAD+ + H2O
show the reaction diagram
-
-
-
?
taxifolin + NADPH + O2
2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
taxifolin + NADH + O2
2,3-dihydrogossypetin + NAD+ + H2O
show the reaction diagram
-
-
-
?
taxifolin + NADPH + O2
2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
twice oxidized compared to NADPH
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6
-
20% of maximal activity
395990
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40
-
25% loss of activity in 10 min
50
-
95% loss of activity in 10 min
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.13.19)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)