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IUBMB Comments A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate).
Synonyms
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4-HPA 1-hydroxylase
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4-hydroxyphenylacetate 1-hydroxylase
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4-hydroxyphenylacetic 1-hydroxylase
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oxygenase, 4-hydroxyphenylacetate 1-mono-
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4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = homogentisate + NAD(P)+ + H2O
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4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)
A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate).
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4-hydroxy-2-methylphenylacetate + NAD(P)H + O2
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Substrates: -
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4-hydroxyhydratropate + NAD(P)H + O2
2-methylhomogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenoxyacetate + ?
hydroquinone + glycolate + ?
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2
homogentisate + NAD+ + H2O
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Substrates: -
r
additional information
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Substrates: low activity with: 4-hydroxyphenylpropionate, 4-hydroxy-3-methylphenylacetate, 3,4-dihydroxyphenylacetate
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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4-hydroxyphenylacetate + NAD(P)H + O2
homogentisate + NAD(P)+ + H2O
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Substrates: -
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FAD
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no effect
NADH
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no activity with NADH
NADH
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same maximal velocity with NADH and NADPH
NADPH
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NADPH
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same maximal velocity with NADH and NADPH
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Mg2+
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required
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3,4-dihydroxyphenylacetic acid
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4-Hydroxy-3-methylphenylacetic acid
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4-hydroxyphenylpropionic acid
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DL-4-hydroxymandelic acid
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0.031
4-hydroxyphenylacetate
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PHPXAa-B
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brenda
PHPXAa-B
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brenda
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brenda
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brenda
CBS3
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brenda
CBS3
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brenda
124X
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brenda
124X
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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A3RTM6_RALSU
Ralstonia solanacearum (strain UW551)
558
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61158
TrEMBL
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E5AKV1_MYCRK
Mycetohabitans rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
119
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13690
TrEMBL
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A0A4Y1MVS5_9PROT
575
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63097
TrEMBL
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4°C, in the presence of dithioerythritol
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Van den Tweel, W.J.J.; Smits, J.P.; de Bont, J.A.M.
Catabolism of DL-alpha-phenylhydracrylic, phenylacetic and 3- and 4-hydroxyphenylacetic acid via homogentisic acid in a Flavobacterium sp.
Arch. Microbiol.
149
207-213
1988
Flavobacterium sp.
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brenda
Hareland, W.A.; Crawford, R.L.; Chapman, P.J.; Dagley, S.
Metabolic function and properties of 4-hydroxyphenylacetic acid 1-hydroxylase from Pseudomonas acidovorans
J. Bacteriol.
121
272-285
1975
Delftia acidovorans
brenda
Van den Tweel, W.J.J.; Janssens, R.J.J.; De Bont, J.A.M.
Degradation of 4-hydroxyphenylacetate by Xanthobacter 124X
Antonie van Leeuwenhoek
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309-318
1986
Xanthomonas sp., Xanthomonas sp. 124X
brenda
Klages, U.; Markus, A.; Lingens, F.
Degradation of 4-chlorophenylacetic acid by a Pseudomonas species
J. Bacteriol.
146
64-68
1981
Pseudomonas sp., Pseudomonas sp. CBS3
brenda
Crawford, R.L.
Hydroxylation of 4-hydroxyphenoxyacetate by a Bacillus sp.
FEMS Microbiol. Lett.
4
233-234
1978
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) PHPXAa-B
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brenda
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