Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.14.13.179 - methylxanthine N3-demethylase

for references in articles please use BRENDA:EC1.14.13.179

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH . Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines.

The enzyme appears in viruses and cellular organisms

Synonyms
ndmB, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-methylxanthine + O2 + NAD(P)H + H+ = xanthine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
theobromine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
Highest Expressing Human Cell Lines
Cell Line Links Gene Links