We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.
The enzyme appears in viruses and cellular organisms
Synonyms
3-(3-hydroxyphenyl)propionate hydroxylase, 3HPP hydroxylase, MhpA,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-(3-hydroxyphenyl)propionate hydroxylase
-
-
3HPP hydroxylase
-
-
MhpA
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+
(2)
-
-
3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
the His-Cys catalytic diad in free papain is fully protonated, -NH(+)/-SH. The experimental pKa of 8.62 for His159 imidazole in free papain is assigned to the -NH(+)/-SH and -N/-SH equilibrium
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating)
A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2
3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O
additional information
?
-
-
MhpA does not oxidize melilotate
-
?
3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2
3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O
-
-
-
ir
3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2
3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O
-
-
-
ir
3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2
3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O
-
-
-
?
3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2
3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NADH
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
no activity in Escherichia coli
-
-
-
brenda
no activity in Escherichia coli LW279
-
-
-
brenda
no activity in Escherichia coli LW303
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
62050
-
calculated from amino acid sequence
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
growth with 3HCI induces the synthesis of enzyme MhpA
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Burlingame, R.; Chapmen, P.J.
Catabolism of phenylpropionic acid and its 3-hydroxy-derivative by Escherichia coli
J. Bacteriol.
155
113-121
1983
Escherichia coli, Escherichia coli KK334
brenda
Burlingame, R.P.; Wyman, L.; Chapman, P.J.
Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation
J. Bacteriol.
168
55-64
1986
no activity in Escherichia coli, no activity in Escherichia coli LW303, no activity in Escherichia coli LW279
brenda
Diaz, E.; Ferrandez, A.; Garcia, J.L.
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12
J. Bacteriol.
180
2915-2923
1998
Escherichia coli
brenda
Ferrandez, A.; Garcia, J.L.; Diaz, E.
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12
J. Bacteriol.
179
2573-2581
1997
Escherichia coli
brenda
Arai, H.; Yamamoto, T.; Ohishi, T.; Shimizu, T.; Nakata, T.; Kudo, T.
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441
Microbiology
145
2813-2820
1999
Comamonas testosteroni, Comamonas testosteroni TA441
brenda
Select items on the left to see more content.
html completed