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Information on EC 1.14.13.106 - epi-isozizaene 5-monooxygenase

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IUBMB Comments
This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
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The expected taxonomic range for this enzyme is: Streptomyces coelicolor
Synonyms
cyp170a1, albaflavenone synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 O2 = albaflavenone + 2 NADP+ + 3 H2O
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overall reaction
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(+)-epi-isozizaene + NADPH + H+ + O2 = (5R)-albaflavenol + NADP+ + H2O
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(+)-epi-isozizaene + NADPH + H+ + O2 = (5S)-albaflavenol + NADP+ + H2O
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(5R)-albaflavenol + NADPH + H+ + O2 = albaflavenone + NADP+ + 2 H2O
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(5S)-albaflavenol + NADPH + H+ + O2 = albaflavenone + NADP+ + 2 H2O
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