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atropine + NADPH + H+ + O2
atropine N-oxide + NADP+ + H2O
-
-
-
?
atropine + NADPH + O2
atropine N-oxide + NADP+ + H2O
21% of the activity with monocrotaline
-
?
axillaridine + NADPH + H+ + O2
axillaridine N-oxide + NADP+ + H2O
-
-
-
?
axillaridine + NADPH + O2
axillaridine N-oxide + NADP+ + H2O
axillarine + NADPH + H+ + O2
axillarine N-oxide + NADP+ + H2O
-
-
-
?
axillarine + NADPH + O2
axillarine N-oxide + NADP+ + H2O
cysteamine + NADPH + H+ + O2
cysteamine N-oxide + NADP+ + H2O
-
-
-
?
heliotrine + NADPH + H+ + O2
heliotrine N-oxide + NADP+ + H2O
-
-
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
indicine + NADPH + H+ + O2
indicine N-oxide + NADP+ + H2O
-
-
-
?
indicine + NADPH + O2
indicine N-oxide + NADP+ + H2O
lycopsamine + NADPH + O2
lycopsamine N-oxide + NADP+ + H2O
monocrotaline + NADPH + H+ + O2
monocrotaline N-oxide + NADP+ + H2O
-
-
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
nicotine + NADPH + H+ + O2
nicotine N-oxide + NADP+ + H2O
-
-
-
?
phalaenopsine + NADPH + H+ + O2
phalaenopsine N-oxide + NADP+ + H2O
-
-
-
?
phalaenopsine + NADPH + O2
phalaenopsine N-oxide + NADP+ + H2O
19% of the activity with monocrotaline
-
?
retronecine + NADPH + H+ + O2
retronecine N-oxide + NADP+ + H2O
-
-
-
?
retrorsine + NADPH + H+ + O2
retrorsine N-oxide + NADP+ + H2O
-
-
-
?
retrorsine + NADPH + O2
retrorsine N-oxide + NADP+ + H2O
rinderine + NADPH + H+ + O2
rinderine N-oxide + NADP+ + H2O
-
-
-
?
rinderine + NADPH + O2
rinderine N-oxide + NADP+ + H2O
sarracine + NADPH + H+ + O2
sarracine N-oxide + NADP+ + H2O
-
-
-
?
senecionine + NADPH + H+ + O2
senecionine N-oxide + NADP+ + H2O
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
seneciphylline + NADPH + H+ + O2
seneciphylline N-oxide + NADP+ + H2O
-
second best substrate
-
?
seneciphylline + NADPH + O2
seneciphylline N-oxide + NADP+ + H2O
senecivernine + NADPH + H+ + O2
senecivernine N-oxide + NADP+ + H2O
-
-
-
?
senecivernine + NADPH + O2
senecivernine N-oxide + NADP+ + H2O
triangularine + NADPH + O2
triangularine N-oxide + NADP+ + H2O
-
60% of the activity with senecionine
-
?
additional information
?
-
axillaridine + NADPH + O2

axillaridine N-oxide + NADP+ + H2O
-
79% of the activity with senecionine
-
?
axillaridine + NADPH + O2
axillaridine N-oxide + NADP+ + H2O
-
93% of the activity with senecionine
-
?
axillaridine + NADPH + O2
axillaridine N-oxide + NADP+ + H2O
-
76% of the activity with senecionine
-
?
axillarine + NADPH + O2

axillarine N-oxide + NADP+ + H2O
69% of the activity with monocrotaline
-
?
axillarine + NADPH + O2
axillarine N-oxide + NADP+ + H2O
-
55% of the activity with senecionine
-
?
axillarine + NADPH + O2
axillarine N-oxide + NADP+ + H2O
-
38% of the activity with senecionine
-
?
axillarine + NADPH + O2
axillarine N-oxide + NADP+ + H2O
-
74% of the activity with senecionine
-
?
axillarine + NADPH + O2
axillarine N-oxide + NADP+ + H2O
74% of the activity with senecionine, native enzyme. 83% of the activity with senecionine, recombinant enzyme
-
?
heliotrine + NADPH + O2

heliotrine N-oxide + NADP+ + H2O
49% of the activity with monocrotaline
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
-
86% of the activity with senecionine
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
-
115% of the activity with senecionine
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
-
-
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
-
25% of the activity with senecionine
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
25% of the activity with senecionine, native enzyme. 49% of the activity with senecionine, recombinant enzyme
-
?
indicine + NADPH + O2

indicine N-oxide + NADP+ + H2O
-
90% of the activity with senecionine
-
?
indicine + NADPH + O2
indicine N-oxide + NADP+ + H2O
-
78% of the activity with senecionine
-
?
indicine + NADPH + O2
indicine N-oxide + NADP+ + H2O
-
35% of the activity with senecionine
-
?
lycopsamine + NADPH + O2

lycopsamine N-oxide + NADP+ + H2O
-
93% of the activity with senecionine
-
?
lycopsamine + NADPH + O2
lycopsamine N-oxide + NADP+ + H2O
-
75% of the activity with senecionine
-
?
lycopsamine + NADPH + O2
lycopsamine N-oxide + NADP+ + H2O
-
20% of the activity with senecionine
-
?
monocrotaline + NADPH + O2

monocrotaline N-oxide + NADP+ + H2O
-
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
-
103% of the activity with senecionine
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
-
110% of the activity with senecionine
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
-
-
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
-
92% of the activity with senecionine
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
92% of the activity with senecionine, native enzyme. 94% of the activity with senecionine, recombinant enzyme
-
?
retrorsine + NADPH + O2

retrorsine N-oxide + NADP+ + H2O
-
as active as senecionine
-
?
retrorsine + NADPH + O2
retrorsine N-oxide + NADP+ + H2O
-
93% of the activity with senecionine
-
?
retrorsine + NADPH + O2
retrorsine N-oxide + NADP+ + H2O
-
97% of the activity with senecionine
-
?
rinderine + NADPH + O2

rinderine N-oxide + NADP+ + H2O
43% of the activity with monocrotaline
-
?
rinderine + NADPH + O2
rinderine N-oxide + NADP+ + H2O
-
79% of the activity with senecionine
-
?
rinderine + NADPH + O2
rinderine N-oxide + NADP+ + H2O
-
81% of the activity with senecionine
-
?
rinderine + NADPH + O2
rinderine N-oxide + NADP+ + H2O
-
23% of the activity with senecionine
-
?
senecionine + NADPH + H+ + O2

senecionine N-oxide + NADP+ + H2O
-
-
-
?
senecionine + NADPH + H+ + O2
senecionine N-oxide + NADP+ + H2O
-
most efficient substrate
-
?
senecionine + NADPH + O2

senecionine N-oxide + NADP+ + H2O
61% of the activity with monocrotaline
-
?
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
-
-
-
?
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
-
-
-
?
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
-
-
-
?
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
-
-
?
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
-
-
?
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
-
-
-
?
seneciphylline + NADPH + O2

seneciphylline N-oxide + NADP+ + H2O
59% of the activity with monocrotaline
-
?
seneciphylline + NADPH + O2
seneciphylline N-oxide + NADP+ + H2O
-
117% of the activity with senecionine
-
?
seneciphylline + NADPH + O2
seneciphylline N-oxide + NADP+ + H2O
-
119% of the activity with senecionine
-
?
seneciphylline + NADPH + O2
seneciphylline N-oxide + NADP+ + H2O
-
95% of the activity with senecionine
-
?
seneciphylline + NADPH + O2
seneciphylline N-oxide + NADP+ + H2O
95% of the activity with senecionine, native enzyme. 93% of the activity with senecionine, recombinant enzyme
-
?
senecivernine + NADPH + O2

senecivernine N-oxide + NADP+ + H2O
-
107% of the activity with senecionine
-
?
senecivernine + NADPH + O2
senecivernine N-oxide + NADP+ + H2O
-
113% of the activity with senecionine
-
?
senecivernine + NADPH + O2
senecivernine N-oxide + NADP+ + H2O
-
81% of the activity with senecionine
-
?
additional information

?
-
the enzyme shows activity with glutathione (41% of the activity with monocrotaline)
-
?
additional information
?
-
-
the enzyme shows activity with glutathione (41% of the activity with monocrotaline)
-
?
additional information
?
-
-
the enzyme N-oxidizes only alkaloids with structural elements which are essential for hepatotoxic and genotoxic pyrrolizidine alkaloids, i.e. 1,2-double bond, esterification of the allylic hydroxyl group, presence of a second free or esterified hydroxyl group at carbon 7. No activity with: triangularine, senkirkine, sarracine, supinine, phalaenopsine, retronecine, heliotridine, supinidine, isoretronecanol, nicotine, caffeine, tropane alkaloids, quinolizidine alkaloids, indole alkaloids, isoquinolines and synthetic heterocyclic tertiary amines
-
?
additional information
?
-
-
the enzyme N-oxidizes only alkaloids with structural elements which are essential for hepatotoxic and genotoxic pyrrolizidine alkaloids, i.e. 1,2-double bond, esterification of the allylic hydroxyl group, presence of a second free or esterified hydroxyl group at carbon 7. No activity with: triangularine, senkirkine, sarracine, supinine, phalaenopsine, retronecine, heliotridine, supinidine, isoretronecanol, nicotine, caffeine, tropane alkaloids, quinolizidine alkaloids, indole alkaloids, isoquinolines and synthetic heterocyclic tertiary amines
-
?
additional information
?
-
the enzyme is highly specific for toxic pyrrolizidine alkaloids. No activity with: senkirkine, dimethylaniline, L-Pro, caffeine, atropine, supinidine, retronecine, phalaenopsine
-
?
additional information
?
-
-
the enzyme is highly specific for toxic pyrrolizidine alkaloids. No activity with: senkirkine, dimethylaniline, L-Pro, caffeine, atropine, supinidine, retronecine, phalaenopsine
-
?
additional information
?
-
-
the enzyme N-oxidizes only alkaloids with structural elements which are essential for hepatotoxic and genotoxic pyrrolizidine alkaloids, i.e. 1,2-double bond, esterification of the allylic hydroxyl group, presence of a second free or esterified hydroxyl group at carbon 7. No activity with: senkirkine, sarracine, supinine, phalaenopsine, retronecine, heliotridine, supinidine, isoretronecanol, nicotine, caffeine, tropane alkaloids, quinolizidine alkaloids, indole alkaloids, isoquinolines and synthetic heterocyclic tertiary amines
-
?
additional information
?
-
the enzyme allows the larvae to feed on pyrrolizidine alkaloid-containing plants and to accumulate predation-deterrent pyrrolizidine alkaloids in the hemolymph
-
?
additional information
?
-
-
the enzyme allows the larvae to feed on pyrrolizidine alkaloid-containing plants and to accumulate predation-deterrent pyrrolizidine alkaloids in the hemolymph
-
?
additional information
?
-
-
no activity with senkirkine, heliotridine, supinidine, ephedrine, dimethylaniline, L-cysteine, hydroxylamine, and glutathione
-
?
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