Information on EC 1.14.11.33 - DNA oxidative demethylase

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EC Tree 1 Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor 1.14.11.33 DNA oxidative demethylase

IUBMB Comments

Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N¹-methyladenine, N³-methylcytosine, N¹-methylguanine, and N³-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.

The enzyme appears in viruses and cellular organisms