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Information on EC 1.14.11.33 - DNA oxidative demethylase

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IUBMB Comments
Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
alkbh3, alkbh2, alkbh8, alkb homolog 1, alkylated dna repair protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
DNA-base-CH3 + 2-oxoglutarate + O2 = DNA-base + formaldehyde + succinate + CO2
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