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Information on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

for references in articles please use BRENDA:EC1.14.11.30

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IUBMB Comments

Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-α, the α subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
hif1an, asparaginyl hydroxylase, factor inhibiting hif-1, factor-inhibiting hif, asparaginyl-hydroxylase, hypoxia-inducible factor 1-alpha inhibitor, hif asparagine hydroxylase, hypoxia-inducible factor asparagine hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 = hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
show the reaction diagram
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