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Information on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

for references in articles please use BRENDA:EC1.14.11.30
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IUBMB Comments
Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
asparaginyl hydroxylase, factor inhibiting hif-1, factor-inhibiting hif, asparaginyl-hydroxylase, hypoxia-inducible factor asparagine hydroxylase, hif asparagine hydroxylase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 = hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
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