Reference on EC 1.14.11.29 - hypoxia-inducible factor-proline dioxygenase
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Hirsila, M.; Koivunen, P.; Gunzler, V.; Kivirikko, K.I.; Myllyharju, J.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
J. Biol. Chem.
278
30772-30780
2003
Homo sapiens, Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Ivan, M.; Kondo, K.; Yang, H.F.; Kim, W.; Valiando, J.; Ohh, M.; Salic, A.; Asara, J.M.; Lane, W.S.; Kaelin, W.G.
HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
Science
292
464-468
2001
Homo sapiens
Jaakkola, P.; Mole, D.R.; Tian, Y.M.; Wilson, M.I.; Gielbert, J.; Gaskell, S.J.; von Kriegsheim, A.; Hebestreit, H.F.; Mukherji, M.; Schofield, C.J.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
Science
292
468-472
2001
Homo sapiens
Bruick, R.K.; McKnight, S.L.
A conserved family of prolyl-4-hydroxylases that modify HIF
Science
294
1337-1340
2001
Drosophila melanogaster, Homo sapiens, Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9)
Pappalardi, M.B.; McNulty, D.E.; Martin, J.D.; Fisher, K.E.; Jiang, Y.; Burns, M.C.; Zhao, H.; Ho, T.; Sweitzer, S.; Schwartz, B.; Annan, R.S.; Copeland, R.A.; Tummino, P.J.; Luo, L.
Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites
Biochem. J.
436
363-369
2011
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Kwon, H.S.; Choi, Y.K.; Kim, J.W.; Park, Y.K.; Yang, E.G.; Ahn, D.R.
Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides
Bioorg. Med. Chem. Lett.
21
4325-4328
2011
Homo sapiens
Cavadas, M.A.; Nguyen, L.K.; Cheong, A.
Hypoxia-inducible factor (HIF) network: insights from mathematical models
Cell Commun. Signal.
11
42
2013
Homo sapiens
Masson, N.; Singleton, R.S.; Sekirnik, R.; Trudgian, D.C.; Ambrose, L.J.; Miranda, M.X.; Tian, Y.M.; Kessler, B.M.; Schofield, C.J.; Ratcliffe, P.J.
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
EMBO Rep.
13
251-257
2012
Homo sapiens
Nguyen, L.K.; Cavadas, M.A.; Scholz, C.C.; Fitzpatrick, S.F.; Bruning, U.; Cummins, E.P.; Tambuwala, M.M.; Manresa, M.C.; Kholodenko, B.N.; Taylor, C.T.; Cheong, A.
A dynamic model of the hypoxia-inducible factor 1alpha (HIF-1alpha) network
J. Cell Sci.
126
1454-1463
2013
Homo sapiens
Geng, Z.; Zhu, J.; Cao, J.; Geng, J.; Song, X.; Zhang, Z.; Bian, N.; Wang, Z.
Effects of polynitrogen compounds on the activity of recombinant human HIF-1alpha prolyl hydroxylase 3 in E. coli
J. Inorg. Biochem.
105
391-399
2011
Homo sapiens
Flagg, S.C.; Martin, C.B.; Taabazuing, C.Y.; Holmes, B.E.; Knapp, M.J.
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)
J. Inorg. Biochem.
113
25-30
2012
Homo sapiens
Pektas, S.; Knapp, M.J.
Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change
J. Inorg. Biochem.
126
55-60
2013
Homo sapiens
Cao, J.; Geng, Z.; Ma, X.; Wen, J.; Yin, Y.; Wang, Z.
Evidence for inhibition of HIF-1alpha prolyl hydroxylase 3 activity by four biologically active tetraazamacrocycles
Org. Biomol. Chem.
10
3913-3923
2012
Homo sapiens
Chen, N.; Huang, C.H.; Chen, B.X.; Liu, H.; Wang, W.M.; Gul, Y.; Wang, H.L.
Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1alpha
Biochem. Biophys. Res. Commun.
469
737-742
2016
Megalobrama amblycephala (A0A140EDB6)
Tarhonskaya, H.; Chowdhury, R.; Leung, I.K.; Loik, N.D.; McCullagh, J.S.; Claridge, T.D.; Schofield, C.J.; Flashman, E.
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
Biochem. J.
463
363-372
2014
Homo sapiens (Q9GZT9), Homo sapiens
Pektas, S.; Taabazuing, C.Y.; Knapp, M.J.
Increased turnover at limiting O2 concentrations by the Thr387 -> Ala variant of HIF-prolyl hydroxylase PHD2
Biochemistry
54
2851-2857
2015
Homo sapiens (Q9GZT9), Homo sapiens
Osipyants, A.; Smirnova, N.; Khristichenko, A.; Hushpulian, D.; Nikulin, S.; Chubar, T.; Zakhariants, A.; Tishkov, V.; Gazaryan, I.; Poloznikov, A.
Enzymesubstrate reporters for evaluation of substrate specificity of HIF prolyl hydroxylase isoforms
Biochemistry
82
1207-1214
2017
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Fan, L.; Li, J.; Yu, Z.; Dang, X.; Wang, K.
The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration
BioMed Res. Int.
2014
239356
2014
Homo sapiens
Hong, Y.R.; Kim, H.T.; Ro, S.; Cho, J.M.; Lee, S.H.; Kim, I.S.; Jung, Y.H.
Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation
Bioorg. Med. Chem. Lett.
24
3142-3145
2014
Homo sapiens
Miikkulainen, P.; Hoegel, H.; Rantanen, K.; Suomi, T.; Kouvonen, P.; Elo, L.L.; Jaakkola, P.M.
HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
Cancer Metab.
5
5-5
2017
Homo sapiens (Q9H6Z9)
Bishop, T.; Ratcliffe, P.J.
HIF hydroxylase pathways in cardiovascular physiology and medicine
Circ. Res.
117
65-79
2015
Homo sapiens
Badawi, Y.; Shi, H.
Relative contribution of prolyl hydroxylase-dependent and -independent degradation of HIF-1alpha by proteasomal pathways in cerebral ischemia
Front. Neurosci.
11
239
2017
Homo sapiens
Wang, L.; Cui, S.; Ma, L.; Kong, L.; Geng, X.
Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates
Insect Mol. Biol.
24
634-648
2015
Caenorhabditis elegans, Drosophila melanogaster
Giannetto, A.; Maisano, M.; Cappello, T.; Oliva, S.; Parrino, V.; Natalotto, A.; De Marco, G.; Barberi, C.; Romeo, O.; Mauceri, A.; Fasulo, S.
Hypoxia-inducible factor alpha and Hif-prolyl hydroxylase characterization and gene expression in short-time air-exposed Mytilus galloprovincialis
Mar. Biotechnol.
17
768-781
2015
Mytilus galloprovincialis (A0A0K0M9M3), Mytilus galloprovincialis
Kapitsinou, P.P.; Rajendran, G.; Astleford, L.; Michael, M.; Schonfeld, M.P.; Fields, T.; Shay, S.; French, J.L.; West, J.; Haase, V.H.
The endothelial prolyl-4-hydroxylase domain 2/hypoxia-inducible factor 2 axis regulates pulmonary artery pressure in mice
Mol. Cell. Biol.
36
1584-1594
2016
Mus musculus
Arsenault, P.R.; Song, D.; Chung, Y.J.; Khurana, T.S.; Lee, F.S.
The zinc finger of prolyl hydroxylase domain protein 2 is essential for efficient hydroxylation of hypoxia-inducible factor alpha
Mol. Cell. Biol.
36
2328-2343
2016
Mus musculus (Q91YE2)
Kozlova, N.; Wottawa, M.; Katschinski, D.M.; Kristiansen, G.; Kietzmann, T.
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
Oncotarget
8
9885-9898
2017
Homo sapiens
Chan, M.C.; Atasoylu, O.; Hodson, E.; Tumber, A.; Leung, I.K.; Chowdhury, R.; Gomez-Perez, V.; Demetriades, M.; Rydzik, A.M.; Holt-Martyn, J.; Tian, Y.M.; Bishop, T.; Claridge, T.D.; Kawamura, A.; Pugh, C.W.; Ratcliffe, P.J.; Schofield, C.J.
Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
PLoS ONE
10
e0132004
2015
Mus musculus (Q91UZ4), Mus musculus (Q91YE2), Mus musculus (Q91YE3), Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Sun, W.; Jelkmann, W.; Depping, R.
Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-alpha
Cell Death Dis.
5
e1322
2014
Homo sapiens (Q9GZT9)
Sun, W.; Kosyna, F.K.; Jelkmann, W.; Depping, R.
Prolyl-4-hydroxylase 2 potentially contributes to hepatocellular carcinoma-associated erythrocytosis by maintaining hepatocyte nuclear factor-4alpha expression
Cell. Physiol. Biochem.
37
2257-2264
2015
Homo sapiens (Q9GZT9), Homo sapiens
Li, J.; Yuan, W.; Jiang, S.; Ye, W.; Yang, H.; Shapiro, I.M.; Risbud, M.V.
Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus
J. Biol. Chem.
290
7195-7207
2015
Rattus norvegicus (P59722), Homo sapiens (Q9GZT9)
Taylor, C.T.; Scholz, C.C.
A PHD in macrophage survival
J. Leukoc. Biol.
96
365-375
2014
Mus musculus (Q91UZ4)
Osipyants, A.I.; Poloznikov, A.A.; Smirnova, N.A.; Hushpulian, D.M.; Khristichenko, A.Y.; Chubar, T.A.; Zakhariants, A.A.; Ahuja, M.; Gaisina, I.N.; Thomas, B.; Brown, A.M.; Gazaryan, I.G.; Tishkov, V.I.
L-ascorbic acid A true substrate for HIF prolyl hydroxylase?
Biochimie
147
46-54
2018
Homo sapiens (Q9GZT9)
Tong, J.; Yu, F.C.; Li, Y.; Wei, Q.; Li, C.; Zhen, P.; Zhang, G.
Prolyl 4-hydroxylase domain protein 3-inhibited smooth-muscle-cell dedifferentiation improves cardiac perivascular fibrosis induced by obstructive sleep apnea
BioMed Res. Int.
2019
9174218
2019
Mus musculus (Q91UZ4)
Hamada, M.; Takayama, T.; Shibata, T.; Hiratate, A.; Takahashi, M.; Yashiro, M.; Takayama, N.; Okumura-Kitajima, L.; Koretsune, H.; Kajiyama, H.; Naruse, T.; Kato, S.; Takano, H.; Kakinuma, H.
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia
Bioorg. Med. Chem. Lett.
28
1725-1730
2018
Homo sapiens (Q9GZT9)
Mbenza, N.M.; Nasarudin, N.; Vadakkedath, P.G.; Patel, K.; Ismail, A.Z.; Hanif, M.; Wright, L.J.; Sarojini, V.; Hartinger, C.G.; Leung, I.K.H.
Carbon monoxide is an inhibitor of HIF prolyl hydroxylase domain 2
ChemBioChem
22
2521-2525
2021
Homo sapiens (Q9GZT9)
Holt-Martyn, J.P.; Chowdhury, R.; Tumber, A.; Yeh, T.L.; Abboud, M.I.; Lippl, K.; Lohans, C.T.; Langley, G.W.; Figg, W.; McDonough, M.A.; Pugh, C.W.; Ratcliffe, P.J.; Schofield, C.J.
Structure-activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
ChemMedChem
15
270-273
2020
Homo sapiens (Q9GZT9)
Poloznikov, A.A.; Nikulin, S.V.; Zakhariants, A.A.; Khristichenko, A.Y.; Hushpulian, D.M.; Gazizov, I.N.; Tishkov, V.I.; Gazaryan, I.G.
''Branched Tail'' oxyquinoline inhibitors of HIF prolyl hydroxylase early evaluation of toxicity and metabolism using liver-on-a-chip
Drug Metab. Lett.
13
45-52
2019
Homo sapiens
Cockman, M.E.; Lippl, K.; Tian, Y.M.; Pegg, H.B.; Figg, W.D.; Abboud, M.I.; Heilig, R.; Fischer, R.; Myllyharju, J.; Schofield, C.J.; Ratcliffe, P.J.
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
eLife
8
e46490
2019
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9), Homo sapiens
Dengler, F.; Sova, S.; Salo, A.M.; Maeki, J.M.; Koivunen, P.; Myllyharju, J.
Expression and roles of individual HIF prolyl 4-hydroxylase isoenzymes in the regulation of the hypoxia response pathway along the murine gastrointestinal epithelium
Int. J. Mol. Sci.
22
4038
2021
Mus musculus (Q8BG58), Mus musculus
Myllykoski, M.; Sutinen, A.; Koski, M.; Kallio, J.; Raasakka, A.; Myllyharju, J.; Wierenga, R.; Koivunen, P.
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
J. Biol. Chem.
296
100197
2021
Homo sapiens (Q9NXG6), Homo sapiens
Chong, M.; Toh, L.; Tumber, A.; Chan, Y.; Chan, M.; Abboud, M.; Schofield, C.; Yeoh, K.
Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes
Med. Chem. Res.
30
977-986
2021
Homo sapiens (Q9GZT9)
-
Pickel, C.; Taylor, C.; Scholz, C.
Genetic knockdown and pharmacologic inhibition of hypoxia-inducible factor (HIF) hydroxylases
Methods Mol. Biol.
1742
1-14
2018
Homo sapiens
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