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Information on EC 1.14.11.21 - clavaminate synthase

for references in articles please use BRENDA:EC1.14.11.21

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IUBMB Comments

Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the β-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site.

The enzyme appears in viruses and cellular organisms

Synonyms
clavaminate synthase, clavaminate synthase 2, clavaminic acid synthase, clavaminate synthase 1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
show the reaction diagram
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
show the reaction diagram
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
show the reaction diagram