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Information on EC 1.13.11.84 - crocetin dialdehyde synthase

for references in articles please use BRENDA:EC1.13.11.84

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IUBMB Comments

The enzyme, characterized from the plant Crocus sativus (saffron), acts twice, cleaving 3β-hydroxy-β-cyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that plant, leading to the different compounds that impart the color, flavor and aroma of the saffron spice. The enzyme can similarly cleave the 7-8 double bond of other carotenoids with a 3-hydroxy-β-carotenoid end group.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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Synonyms
carotenoid cleavage dioxygenase 2, zeaxanthin 7,8(7',8')-cleavage dioxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3beta-hydroxy-8'-apo-beta-carotenal + O2 = crocetin dialdehyde + 3beta-hydroxy-beta-cyclocitral
show the reaction diagram
(1b)
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zeaxanthin + 2 O2 = crocetin dialdehyde + 2 3beta-hydroxy-beta-cyclocitral
show the reaction diagram
overall reaction
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zeaxanthin + O2 = 3beta-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral
show the reaction diagram
(1a)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
carotenoid cleavage
Highest Expressing Human Cell Lines
Cell Line Links Gene Links