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Information on EC 1.13.11.58 - linoleate 9S-lipoxygenase

for references in articles please use BRENDA:EC1.13.11.58

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IUBMB Comments

Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and α-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate . EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
9-lipoxygenase, zmlox3, r9-lox1, zmlox5, calox1, atlox1, epidermal lipoxygenase-3, ghlox1, linoleate 9s-lipoxygenase, nb-9-lox, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
9-lipoxygenase and 9-allene oxide synthase pathway, 9-lipoxygenase and 9-hydroperoxide lyase pathway, alpha-linolenate metabolites biosynthesis, divinyl ether biosynthesis I, linoleate metabolites biosynthesis, vernolate biosynthesis III