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The expected taxonomic range for this enzyme is: Pyrococcus furiosus
Synonyms wor 4, h2:sulfur oxidoreductase, more
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H2 + sulfur = H2S
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H2:sulfur oxidoreductase
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H2 + sulfur
H2S
Substrates: - Products: -
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additional information
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Substrates: catalytic model system of the WOR4 enzyme, reduction of S(8) to H2S via W(VI)O(S2) complex with the aromatic dithiolene ligand Products: -
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Calcium
tungsten-containing enzyme, contains approximately one tungsten three iron, three or four acid-labile sulfide, and one cacium atom per subunit
Iron
tungsten-containing enzyme, contains approximately one tungsten three iron, three or four acid-labile sulfide, and one cacium atom per subunit. Presence of an unusual iron-sulfur chromophore
Tungsten
tungsten-containing enzyme, contains approximately one tungsten three iron, three or four acid-labile sulfide, and one cacium atom per subunit
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additional information
the specific tungsten content is 14.2 nmol/mg, 119fold purification
additional information
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the specific tungsten content is 14.2 nmol/mg, 119fold purification
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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physiological function
the enzyme has a role in sulfur metabolism
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O93736_9EURY
622
0
69369
TrEMBL
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69000
2 * 69000, SDS-PAGE
69363
2 * 69363, calculated from sequence
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homodimer
2 * 69000, SDS-PAGE
homodimer
2 * 69363, calculated from sequence
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moderately expressed and slightly upregulated in presence of sulfur
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Sugimoto, H.; Tano, H.; Toyota, K.; Tajima, R.; Miyake, H.; Takahashi, I.; Hirota, S.; Itoh, S.
Reduction of bis(dithiolene)oxo(disulfido)tungsten(VI) complex with dihydrogen related to the chemical function of the fourth tungsten-containing enzyme (WOR4) from Pyrococcus furiosus
J. Am. Chem. Soc.
132
8-9
2010
Pyrococcus furiosus (O93736)
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Schut, G.J.; Zhou, J.; Adams, M.W.
DNA microarray analysis of the hyperthermophilic archaeon Pyrococcus furiosus: evidence for anNew type of sulfur-reducing enzyme complex
J. Bacteriol.
183
7027-7036
2001
Pyrococcus furiosus (O93736)
brenda
Roy, R.; Adams, M.W.
Characterization of a fourth tungsten-containing enzyme from the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
184
6952-6956
2002
Pyrococcus furiosus (O93736), Pyrococcus furiosus
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