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(-)-epicatechin + H2O2
? + H2O
-
-
-
-
?
1-acetyl-4-(methylsulfanyl)benzene + H2O2 + H+
?
-
-
-
-
?
1-chloro-4-(methylsulfanyl)benzene + H2O2 + H+
?
-
-
-
-
?
1-methoxy-4-(methylsulfanyl)benzene + H2O2 + H+
?
-
-
-
-
?
1-methyl-4-(methylsulfanyl)benzene + H2O2 + H+
?
-
-
-
-
?
1-nitro-4-(methylsulfanyl)benzene + H2O2 + H+
?
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + Br- + H2O2
?
-
the formation of bromohydrins by the MPO-H2O2-bromide system using physiological chloride concentrations occurs only at acidic pH values but not at pH 7.4
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + Cl- + H2O2
?
-
the formation of chlorohydrins by the MPO-H2O2-chloride system using physiological chloride concentrations occurs only at acidic pH values but not at pH 7.4
-
-
?
10-acetyl-3,7-dihydroxyphenoxazine + H2O2 + H+
resorufin + H2O
2,2'-azino-bis-(3-ethylbenzthiazole-6-sulfonic acid) + H2O2
? + H2O
-
both properoxinectin and peroxinectin are catalytically active as peroxidases
-
-
?
2,2'-azino-bis-(3-ethylbenzthiazole-6-sulfonic acid) + H2O2 + H+
?
-
-
-
?
2,2'-azino-bis-(3-ethylbenzthiazole-6-sulfonic acid) + H2O2 + H+
oxidized 2,2'-azino-bis-(3-ethylbenzthiazole-6-sulfonic acid) + H2O
-
-
-
-
?
2-phenylenediamine + H2O2
?
-
-
-
-
?
3,3',5,5'-tetramethylbenzidine + H2O2 + H+
?
-
-
-
?
3,4-dihydroxyphenylacetic acid + H2O2
? + H2O
4-(methylsulfanyl)aniline + H2O2 + H+
?
-
-
-
-
?
4-tolyl methyl sulfide + H2O2 + H+
?
-
-
-
-
?
5-cyanoindole + H2O2
?
-
-
-
-
?
5-hydroxytryptamine + H2O2
?
-
-
-
-
?
5-nitroindole + H2O2
?
-
-
-
-
?
Amplex Red + H2O2
resorufin + H2O
i.e. 10-acetyl-2,7-dihydroxyphenoxazine
-
-
?
Amplex Red + H2O2 + H+
resorufin + H2O
-
-
-
?
apolipoprotein A-I + H2O2 + H+
?
-
-
-
-
?
benzothiophene + H2O2 + H+
?
-
-
-
-
?
benzyl methyl sulfide + H2O2 + H+
?
-
-
-
-
?
Br- + H2O2
HBrO + H2O
-
at physiological concentrations of chloride and bromide, hypobromous acid can be a major oxidant produced by myeloperoxidase
-
-
?
Br- + H2O2 + H+
?
-
-
-
-
?
Br- + H2O2 + H+
HBrO + H2O
chloride + H2O2
hypochlorous acid + H2O
-
-
-
-
?
Cl- + H2O2
HOCl + H2O
-
-
-
?
Cl- + H2O2 + chloroacetonitrile
HClO + H2O + cyanide
-
chloride ion (Cl-) is the dominant electron donor, chloroacetonitrile is activated to cyanide by myeloperoxidase/H2O2/Cl- system in vitro
-
-
?
Cl- + H2O2 + H+
HClO + H2O
Cl- + H2O2 + H+ + taurine + H+
taurine monochloroamine + 2 H2O
donor + H2O2
oxidized donor + H2O
donor + HOCl
oxidized donor + Cl-
guaiacol + H2O2
?
-
at neutral pH MPO has higher affinity to peroxidase substrate guaiacol
-
-
?
guaiacol + H2O2
tetraguaiacol + H2O
hydroethidine + Cl- + H2O2 + H+
2-chloroethidium + H2O
-
-
-
?
I- + H2O2 + H+
?
-
-
-
-
?
indole + H2O2
?
-
-
-
-
?
L-tyrosine + Cl- + H2O2 + H+
3-chloro-L-tyrosine + H2O
-
-
-
?
L-tyrosine + H2O2 + H+
?
-
-
-
?
L-tyrosine + H2O2 + H+
? + H2O
-
-
-
?
L-tyrosine + H2O2 + H+
dityrosine + H2O
-
-
-
?
low density lipoprotein + H2O2 + H+
? + H2O
-
-
-
?
low-density lipoprotein + Cl- + H2O2
? + H2O
-
enzyme produces oxidative modifications of the protein moiety of low density lipoproteins
-
?
monochlorodimedon + Cl-
dichlorodimedon
-
-
-
-
?
monochlorodimedone + H2O2
?
-
-
-
-
?
monochlorodimedone + H2O2
dichlorodimedone + H2O
-
-
-
-
?
myricitrin + H2O2
? + H2O
-
myeloperoxidase is less efficient at oxidizing myricitrin at higher concentrations (0.05 mM) of H2O2
-
-
?
NADH + O2 + H+
NAD+ + H2O2
-
myeloperoxidase is capable of catalyzing an oscillating peroxidase-oxidase reaction, when chloride is present in the reaction mixture
-
-
?
nitric oxide + H2O2
?
-
-
-
?
nitrite + L-tyrosine + H2O2 + H+
?
-
poor substrate for myeloperoxidase, but free tyrosine facilitates nitration of tyrosyl residues by acting as a cosubstrate in the reaction
-
-
?
o-dianisidine + H2O2
oxidized o-dianisidine + H2O
-
-
-
-
?
o-dianisidine + H2O2 + H+
?
-
-
-
?
o-dianisidine + H2O2 + H+
oxidized o-dianisidine + H2O
-
-
-
-
?
ortho-dianisidine + H2O2 + H+
oxidized ortho-dianisidine + H2O
-
-
-
?
phenyl propan-2-yl sulfide + H2O2 + H+
?
-
-
-
-
?
quercetin + H2O2
oxidized quercetin + H2O
-
-
-
?
serotonin + H2O2
serotonin dimer + H2O
favoured substrate of myeloperoxidase, only ascorbate blocks oxidation of serotonin
-
-
?
serotonin + H2O2 + H+
tryptamine dione + H2O
-
-
-
?
serotonin + superoxide
tryptamine-4,5-dione + H2O
-
-
-
?
taurine + Cl- + H2O2
taurine chloramine + H2O
tetramethylbenzidine + H2O2
?
-
-
-
-
?
tetramethylbenzidine + H2O2 + H+
?
-
-
-
-
?
thioanisole + H2O2 + H+
?
-
-
-
-
?
thiocyanate + H2O2
hypothiocyanite + H2O
thiocyanate + H2O2 + H+
?
thiocyanate + H2O2 + H+
hypothiocyanate + H2O
thiocyanate + H2O2 + H+
hypothiocyanite + H2O
thiocyanate + H2O2 + H+
hypothiocyanous acid + H2O
-
-
-
?
tryptamine + H2O2
?
-
-
-
-
?
tyrosine + H2O2
dityrosine + H2O
-
-
-
?
urate + H2O2
5-hydroxyisourate + H2O
-
-
-
-
?
urate + H2O2 + H+
?
-
-
-
?
additional information
?
-
10-acetyl-3,7-dihydroxyphenoxazine + H2O2 + H+
resorufin + H2O
-
-
-
-
?
10-acetyl-3,7-dihydroxyphenoxazine + H2O2 + H+
resorufin + H2O
-
-
-
?
3,4-dihydroxyphenylacetic acid + H2O2
? + H2O
-
-
-
-
?
3,4-dihydroxyphenylacetic acid + H2O2
? + H2O
-
-
-
-
?
ascorbate + H2O2
?
-
-
-
-
?
ascorbate + H2O2
?
-
-
-
?
Br- + H2O2
?
-
-
-
?
Br- + H2O2 + H+
HBrO + H2O
-
-
-
-
?
Br- + H2O2 + H+
HBrO + H2O
-
-
-
?
catechol + H2O2
? + H2O
-
-
-
-
?
catechol + H2O2
? + H2O
-
-
-
-
?
Cl- + H2O2
HClO + H2O
-
-
-
-
?
Cl- + H2O2
HClO + H2O
main reducing substrate for myeloperoxidase
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
711123, 711124, 711125, 711274, 711350, 711881, 711882, 711998, 712340, 712342, 712353, 712361, 713436, 741769, 742084, 764118, 764297, 764466 -
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
physiological substrate of myeloperoxidase
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
at acidic pH, chlorinating activity of MPO dominates
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
?
Cl- + H2O2 + H+
HClO + H2O
-
-
-
-
?
Cl- + H2O2 + H+ + taurine + H+
taurine monochloroamine + 2 H2O
-
the taurine chlorination reaction mediated by the myeloperoxidase system in vivo may involve an enzyme intermediate species rather than free HOCl
-
-
?
Cl- + H2O2 + H+ + taurine + H+
taurine monochloroamine + 2 H2O
-
-
-
?
donor + H2O2
oxidized donor + H2O
-
-
-
-
r
donor + H2O2
oxidized donor + H2O
-
involved in immune defense reactions
-
-
r
donor + HOCl
oxidized donor + Cl-
-
-
-
-
r
donor + HOCl
oxidized donor + Cl-
-
involved in immune defense reactions
-
-
r
dopamine + H2O2
? + H2O
-
-
-
-
?
dopamine + H2O2
? + H2O
-
-
-
-
?
guaiacol + H2O2
tetraguaiacol + H2O
-
-
-
-
?
guaiacol + H2O2
tetraguaiacol + H2O
-
-
-
-
?
I- + H2O2
?
Armoracia sp.
-
-
-
-
?
I- + H2O2
?
-
myeloperoxidase plays a fundamental role in oxidant production by neutrophils
-
-
?
I- + H2O2 + H+
HIO + H2O
-
-
-
-
?
I- + H2O2 + H+
HIO + H2O
iodide is a better electron donor for MPO compound I than Br-
-
-
?
o-dianisidine + H2O2
?
-
-
-
-
?
o-dianisidine + H2O2
?
-
-
-
-
?
SCN- + H2O2
OSCN- + H2O
-
-
-
-
?
SCN- + H2O2
OSCN- + H2O
-
-
-
-
?
taurine + Cl- + H2O2
taurine chloramine + H2O
-
-
-
?
taurine + Cl- + H2O2
taurine chloramine + H2O
-
-
-
-
?
thiocyanate + H2O2
hypothiocyanite + H2O
-
-
-
-
?
thiocyanate + H2O2
hypothiocyanite + H2O
-
-
-
?
thiocyanate + H2O2 + H+
?
-
-
-
-
?
thiocyanate + H2O2 + H+
?
-
-
-
?
thiocyanate + H2O2 + H+
hypothiocyanate + H2O
-
-
-
?
thiocyanate + H2O2 + H+
hypothiocyanate + H2O
-
-
-
-
?
thiocyanate + H2O2 + H+
hypothiocyanite + H2O
-
thiocyanate is a major physiological substrate of myeloperoxidase and most favoured substrate compared to chloride and bromide
-
-
?
thiocyanate + H2O2 + H+
hypothiocyanite + H2O
-
thiocyanate is the most favoured substrate compared to chloride and bromide. With 0.1 mM thiocyanate about 50% of the H2O2 present is converted into hypothiocyanite, the rate of H2O2 loss catalysed by myeloperoxidase in the presence of 100 mM chloride doubles when 0.1 mM thiocyanate is added, and is maximal with 1 mM thiocyanate
-
-
?
tyrosine + H2O2
?
-
-
-
-
?
tyrosine + H2O2
?
-
-
-
?
additional information
?
-
-
analysis of kinetics for eosinophil peroxidase and myeloperoxidase
-
-
?
additional information
?
-
-
antimicrobial function
-
-
?
additional information
?
-
-
myeloperoxidase kills microorganisms via a reaction that involves H2O2 and a halide
-
-
?
additional information
?
-
-
possible role of the enzyme for neutrophil myeloperoxidase in cystic fibrosis lung disease
-
-
?
1.11.2.2 myeloperoxidase
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