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Disease on EC 1.11.1.24 - thioredoxin-dependent peroxiredoxin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis.
Abortion, Spontaneous
Preoxiredoxin family members (Prx3 and Prx4) and pregnancy disorder (recurrent pregnancy loss).
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Acquired Immunodeficiency Syndrome
Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae.
MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells.
Acute Lung Injury
Peroxiredoxin 1 inhibits lipopolysaccharide-induced oxidative stress in lung tissue by regulating P38/JNK signaling pathway.
Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury.
[Roles of peroxiredoxin 6 in the regulation of oxidative stress to lipopolysaccharide-induced acute lung injury].
Adenocarcinoma
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.
ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity.
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Peroxiredoxins, a novel protein family in lung cancer.
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Adenocarcinoma of Lung
DACH1 inhibits the proliferation and invasion of lung adenocarcinoma through the downregulation of peroxiredoxin 3.
Downregulation of peroxiredoxin-1 by ?-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts.
Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I.
Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I.
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer.
The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma.
[Preparation and characterization of human phage display antibody against peroxiredoxin I of lung adenocarcinoma]
Adenoma
Membrane bound Peroxiredoxin-1 serves as a biomarker for in vivo detection of sessile serrated adenomas.
Adenoma, Oxyphilic
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Adenoma, Pleomorphic
Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation.
Adenomatous Polyposis Coli
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Adenoviridae Infections
Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.
Alzheimer Disease
Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model.
Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxin 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer's disease.
Peroxiredoxin I regulates the component expression of ?-secretase complex causing the Alzheimer's disease.
Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
Anemia
Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.
Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia.
Erythrocytes as a preferential target of oxidative stress in blood.
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse.
Anemia, Hemolytic
Gene expression profiling related to the enhanced erythropoiesis in mouse bone marrow cells.
Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane.
Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte.
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice.
Anemia, Hypochromic
NTRC and Chloroplast-Generated Reactive Oxygen Species Regulate Pseudomonas syringae pv. tomato Disease Development in Tomato and Arabidopsis.
Anemia, Sickle Cell
Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia.
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Anthrax
Immunoproteomically identified GBAA_0345, alkyl hydroperoxide reductase subunit C is a potential target for multivalent anthrax vaccine.
S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection.
Aortic Aneurysm
Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Aortic Aneurysm, Abdominal
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm.
Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans.
Aortic Aneurysm, Thoracic
Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Arrhythmias, Cardiac
Programmable VT detection enhancements in implantable cardioverter defibrillator therapy.
Arteritis
Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease.
Arthritis
Exacerbation of collagen antibody-induced arthritis in transgenic mice overexpressing peroxiredoxin 6.
Arthritis, Rheumatoid
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes.
Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles.
Asthenozoospermia
TAT-peroxiredoxin 2 Fusion Protein Supplementation Improves Sperm Motility and DNA Integrity in Sperm Samples from Asthenozoospermic Men.
[Peroxiredoxin I in sperm and reactive oxygen species in seminal plasma in patients with idiopathic asthenozoospermia].
Asthma
Differential role of peroxiredoxin II (PrxII) on the expression of toll-like receptor 4 (TLR4) and B-cell activating factor (BAFF) in ovalbumin (OVA)-induced mouse asthma.
Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity.
Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma.
Astrocytoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Proteomic studies on low- and high-grade human brain astrocytomas.
[Expressions of peroxiredoxin 1, peroxiredoxin 6 and GFAP in human brain astrocytoma and their clinical significance].
Atherosclerosis
Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.
Overexpression of peroxiredoxin 4 attenuates atherosclerosis in apolipoprotein e knockout mice.
Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice.
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
Autoimmune Diseases
A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease.
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Babesiosis
Genome Editing of Babesia bovis Using the CRISPR/Cas9 System.
Bacterial Infections
Characterization of 2-Cys peroxiredoxin 3 and 4 in common carp and the immune response against bacterial infection.
Molecular characterization and functional activity of Prx1 in grass carp (Ctenopharyngodon idella).
Barrett Esophagus
Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.
Behcet Syndrome
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
beta-Thalassemia
Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.
Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase.
Bone Neoplasms
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Bradycardia
Initial single-center experience with an advanced third-generation investigational defibrillator.
Brain Edema
Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death.
Brain Injuries
Correction to: Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2.
Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2.
Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition.
Brain Injuries, Traumatic
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage.
Brain Ischemia
Differences in the protein expression levels of Trx2 and Prx3 in the hippocampal CA1 region between adult and aged gerbils following transient global cerebral ischemia.
Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury.
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
[DAMPs (damage-associated molecular patterns) and inflammation].
Breast Neoplasms
Autoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma.
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.
GATA-binding protein 1 is a novel transcription regulator of peroxiredoxin 5 in human breast cancer cells.
Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.
Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.
Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells.
Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma.
Overexpression of peroxiredoxin in human breast cancer.
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Peroxiredoxin I and II inhibit H(2)O(2)-induced cell death in MCF-7 cell lines.
Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines.
Peroxiredoxin overexpression in MCF-7 breast cancer cells and regulation by cell proliferation and oxidative stress.
Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity.
Peroxiredoxin V: A candidate breast tumor marker of population specificity.
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer.
PRDX4 and Its Roles in Various Cancers.
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.
Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death.
Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents.
The Prognosis Of Peroxiredoxin Family In Breast Cancer.
The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells.
The role of peroxiredoxin II in chemoresistance of breast cancer cells.
The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells.
Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin.
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
[Effect of peroxiredoxin I gene silencing on the radiosensitivity of breast carcinoma MCF-7 cell xenograft in nude mice].
Brucellosis
Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species.
Carcinogenesis
Atrazine affects phosphoprotein and protein expression in MCF-10A human breast epithelial cells.
Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V79 Cells.
Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate.
Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value.
Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma.
Evaluation of Efficacy and Toxicity of Exfoliated Silicate Nanoclays as a Feed Additive for Fumonisin Detoxification.
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.
Human peroxiredoxin 1 modulates TGF-?1-induced epithelial-mesenchymal transition through its peroxidase activity.
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
Peroxiredoxin 1 promotes invasion and migration by regulating epithelial-to-mesenchymal transition during oral carcinogenesis.
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia.
Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer.
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
PRDX1 is a Tumor Suppressor for Nasopharyngeal Carcinoma by Inhibiting PI3K/AKT/TRAF1 Signaling.
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.
PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.
Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells.
PRDX4 and Its Roles in Various Cancers.
Progression of secondary hyperparathyroidism involves deregulation of genes related to DNA and RNA stability.
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Role of peroxiredoxin I in rectal cancer and related to p53 status.
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
[Proteomic analysis of proteins related to radiation-induced carcinogenesis]
Carcinoma
Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma.
Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells.
Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth.
Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum].
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma.
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus.
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions.
Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma.
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation.
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer.
Peroxiredoxin IV protects cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma.
Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells.
Peroxiredoxins, a novel protein family in lung cancer.
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/?-catenin and AKT pathways.
Proteomic analysis and characterisation of human cervico-vaginal fluid proteins.
Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6.
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.
Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation.
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
[Proteomic identification and comparison of differentiation-related proteins in gastric carcinoma cell lines]
[Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE].
Carcinoma, Hepatocellular
Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.
Detection and identification of peroxiredoxin 3 as a biomarker in hepatocellular carcinoma by a proteomic approach.
Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma.
Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells.
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma.
Peroxiredoxin 1, restraining cell migration and invasion, is involved in hepatocellular carcinoma recurrence.
Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the ?-catenin/ID2 pathway.
Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells.
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells.
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Persistent hepatitis C virus infection impairs ribavirin antiviral activity through clathrin-mediated trafficking of equilibrative nucleoside transporter 1.
Plasma nuclear factor kappa B and serum peroxiredoxin 3 in early diagnosis of hepatocellular carcinoma.
PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
[The expression of peroxiredoxin II in hepatocellular carcinoma and its significance]
Carcinoma, Lewis Lung
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
Carcinoma, Mucoepidermoid
Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
Carcinoma, Non-Small-Cell Lung
Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer.
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Proteomic and genomic biomarkers for Non-Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha-1 antitrypsin.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Carcinoma, Ovarian Epithelial
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer.
Carcinoma, Papillary
Peroxiredoxin I expression in human thyroid tumors.
Carcinoma, Renal Cell
Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth.
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
[Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE].
Carcinoma, Squamous Cell
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus.
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Peroxiredoxin IV protects cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma.
Peroxiredoxins, a novel protein family in lung cancer.
Proteomic analysis and characterisation of human cervico-vaginal fluid proteins.
REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.
Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway.
Cardiomegaly
Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy.
Peroxiredoxin-1 ameliorates pressure overload-induced cardiac hypertrophy and fibrosis.
Cardiomyopathies
Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.
Cardiomyopathy, Dilated
(Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure.
Cardiotoxicity
Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4.
Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells.
Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis.
Cardiovascular Diseases
Peroxiredoxin 4, a novel circulating biomarker for oxidative stress and the risk of incident cardiovascular disease and all-cause mortality.
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
The left ventricle proteome differentiates middle-aged and old left ventricles in mice.
Cataract
Localization and H2O2-specific induction of PRDX3 in the eye lens.
Reduced expression of 1-cys peroxiredoxin in oxidative stress-induced cataracts.
Cerebral Hemorrhage
Peroxiredoxin 1-mediated activation of TLR4/NF-?B pathway contributes to neuroinflammatory injury in intracerebral hemorrhage.
Cerebral Infarction
Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction.
Identifying patients with cerebral infarction within the time window compatible with reperfusion therapy, diagnostic performance of glutathione S-transferase-? (GST-?) and peroxiredoxin 1 (PRDX1): exploratory prospective multicentre study FLAG-1 protocol.
Cholangiocarcinoma
Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma.
Cholesteatoma
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Cholesteatoma, Middle Ear
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Chondrosarcoma
SF2523 inhibits human chondrosarcoma cell growth in vitro and in vivo.
Colitis
Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells.
Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis.
Colitis, Ulcerative
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry.
Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model.
Colonic Neoplasms
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.
Peroxiredoxin 5 promotes the epithelial-mesenchymal transition in colon cancer.
Peroxiredoxin V Reduces ?-Lapachone-induced Apoptosis of Colon Cancer Cells.
Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression.
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Telomerase can't handle the stress.
The critical role of peroxiredoxin-2 in colon cancer stem cells.
Colorectal Neoplasms
High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor.
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Multi-panel assay of serum autoantibodies in colorectal cancer.
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.
Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer.
Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.
Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/?-catenin signaling.
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells.
PRDX4 and Its Roles in Various Cancers.
Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients.
Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
Corneal Dystrophies, Hereditary
Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy.
Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy.
Coronary Artery Disease
[Concentration of proinflammatory cytokines, peroxiredoxin-1 and glutathione peroxidase activity in the blood plasma of patients with coronary artery disease undergoing coronary artery bypass grafting].
Coronary Occlusion
Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model.
COVID-19
Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-?/mTOR/BRD4 inhibitor.
Crohn Disease
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.
Cryptorchidism
Impaired expression of peroxiredoxin 4 in damaged testes by artificial cryptorchidism.
Cysticercosis
Taenia solium: antioxidant metabolism enzymes as targets for cestocidal drugs and vaccines.
Cysts
Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis.
Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts.
Quantitative Proteomic Analysis and Evaluation of the Potential Prognostic Biomarkers in Cholangiocarcinoma.
Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Diabetes Mellitus
Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling.
Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus.
Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection.
Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28).
Diabetes Mellitus, Type 1
Peroxiredoxin III protects pancreatic {beta} cells from apoptosis.
Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection.
Diabetes Mellitus, Type 2
Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study.
Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats.
PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL.
Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus.
Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28).
Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes.
Diabetic Cardiomyopathies
Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy.
Diabetic Nephropathies
Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy.
dimethylargininase deficiency
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Down Syndrome
Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains.
Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
Drug Hypersensitivity
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.
Dry Eye Syndromes
Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique.
Dysentery, Amebic
Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence.
Echinococcosis
Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage.
Preliminary Evaluation of Recombinant EPC1 and TPx for Serological Diagnosis of Animal Cystic Echinococcosis.
Thioredoxin peroxidase from Echinococcus granulosus: a candidate to extend the antigenic panel for the immunodiagnosis of human cystic echinococcosis.
Elephantiasis, Filarial
Brugia malayi thioredoxin peroxidase as a potential vaccine candidate antigen for lymphatic filariasis.
Evaluation of immunoprophylactic efficacy of Brugia malayi transglutaminase (BmTGA) in single and multiple antigen vaccination with BmALT-2 and BmTPX for human lymphatic filariasis.
Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis.
Endometrial Hyperplasia
Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer.
Endometrial Neoplasms
Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer.
Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer.
Peroxiredoxin 3 maintains the survival of endometrial cancer stem cells by regulating oxidative stress.
Endometriosis
An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease.
Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts.
Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer.
Esophageal Neoplasms
Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.
Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.
Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6.
Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway.
Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation.
Esophageal Squamous Cell Carcinoma
Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma.
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/?-catenin and AKT pathways.
Fanconi Anemia
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
Fatty Liver
Liver proteomics in progressive alcoholic steatosis.
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Fatty Liver, Alcoholic
The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver.
Fetal Alcohol Spectrum Disorders
Catalase and peroxiredoxin 5 protect Xenopus embryos against alcohol-induced ocular anomalies.
Fibrosarcoma
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Fuchs' Endothelial Dystrophy
Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy.
Gallstones
Identification of cholesterol gallstone with two-dimensional gel electrophoresis and mass spectrometry.
Gastritis
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity.
Gastrointestinal Neoplasms
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells.
Gastrointestinal Stromal Tumors
PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway.
Glioblastoma
Biomarker discovery: a proteomic approach for brain cancer profiling.
High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).
Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells.
Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.
Proteomic studies on low- and high-grade human brain astrocytomas.
Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.
The role of peroxiredoxin II in chemoresistance of breast cancer cells.
Glioma
Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).
Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.
lnc-NLC1-C inhibits migration, invasion and autophagy of glioma cells by targeting miR-383 and regulating PRDX-3 expression.
MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells.
Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.
Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.
The role of peroxiredoxin II in chemoresistance of breast cancer cells.
Tissue Proteome Analysis of Different Grades of Human Gliomas Provides Major Cues for Glioma Pathogenesis.
Goiter
Peroxiredoxin 5 expression in the human thyroid gland.
Graves Disease
Peroxiredoxin 5 expression in the human thyroid gland.
Peroxiredoxin I expression in human thyroid tumors.
Head and Neck Neoplasms
The role of peroxiredoxin II in chemoresistance of breast cancer cells.
Hearing Loss
Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.
Hearing Loss, Sensorineural
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Heart Arrest
CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome.
Heart Failure
(Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure.
Protective role of peroxiredoxin-4 in heart failure.
Proteomic analysis of left ventricular remodeling in an experimental model of heart failure.
Hemangiosarcoma
Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells.
Hepatitis
Laser capture microdissection in comparative proteomic analysis of hepatocellular carcinoma.
Proteome analysis of hepatocellular carcinoma by laser capture microdissection.
Hepatitis B
Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma.
Hepatoblastoma
Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation.
Hepatolenticular Degeneration
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.
Herpes Zoster
Identification of differentially expressed reproductive and metabolic proteins in the female abalone (Haliotis laevigata) gonad following artificial induction of spawning.
Imbalanced testicular metabolism induced by thyroid disorders: New evidences from quantitative proteome.
HIV Infections
HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.
Hodgkin Disease
Differential protein expression of peroxiredoxin-1 in classical Hodgkin Lymphoma: a possible correlation to clinical behaviour.
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.
Hydronephrosis
Peroxiredoxin I protein, a potential biomarker of hydronephrosis in fetal mice exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hyperalgesia
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Hyperglycemia
Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos.
Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy.
Hyperhomocysteinemia
Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
Hypersensitivity
Humoral and in vivo cellular immunity against the raw insect-derived recombinant Leishmania infantum antigens KMPII, TRYP, LACK, and papLe22 in dogs from an endemic area.
Hypertension
Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle.
Peroxiredoxin 4 levels in patients with PCOS and/or obesity.
S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function.
Hyperthyroidism
Peroxiredoxin 5 expression in the human thyroid gland.
Redox Regulation of Myocardial ERK 1/2 Phosphorylation in Experimental Hyperthyroidism: Role of Thioredoxin - Peroxiredoxin System.
Idiopathic Pulmonary Fibrosis
Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study.
Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis.
The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction.
Infections
A study of the interaction between H. pylori mice passage strains and gastric epithelial cells.
Analysis of thioredoxin peroxidase as a promising antigen for diagnosis of Fasciola gigantica infection A preliminary study.
Biology of Zika Virus Infection in Human Skin Cells.
Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation.
Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients.
Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species.
Cofilin-1, peroxiredoxin-1, and galectin-3: Major proteins released by macrophages infected with Corynebacterium pseudotuberculosis.
Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence.
Comparison of gene expression of pyruvate kinase and tryparedoxin peroxidase in metacyclic promastigote forms of Leishmania (L.) tropica and L. major by real-time PCR
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Differential proteomic analysis of children infected with respiratory syncytial virus.
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
Essential role of the peroxiredoxin 4 in Procambarus clarkii antioxidant defense and immune responses.
Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection.
Excretory/secretory products from in vitro-cultured Echinococcus granulosus protoscoleces.
Expression profiles of peroxiredoxins in liver stage of the rodent malaria parasite Plasmodium berghei.
Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage.
Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.
Identification and characterization of atypical 2-cysteine peroxiredoxins from mud crab Scylla paramamosain: The first evidence of two peroxiredoxin 5 genes in non-primate species and their involvement in immune defense against pathogen infection.
Identification of a thioredoxin peroxidase gene involved in resistance to nucleopolyhedrovirus infection in Helicoverpa armigera with RNA interference.
Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract.
Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication.
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity.
JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection.
Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.
Litopenaeus vannamei peroxiredoxin 2-like is involved in WSSV infection by interaction with wsv089 and VP26.
Molecular cloning, expression analysis and characterization of peroxiredoxin during WSSV infection in shrimp Fenneropenaeus indicus.
Molecular cloning, expression and enzymatic activity of a thioredoxin peroxidase from Dirofilaria immitis.
Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis.
Molecular structure and functional characterization of the peroxiredoxin 5 in Procambarus clarkii following LPS and Poly I:C challenge.
Oligomerization dynamics and functionality of Trypanosoma cruzi cytosolic tryparedoxin peroxidase as peroxidase and molecular chaperone.
Peroxiredoxin 1 protects the pea aphid Acyrthosiphon pisum from oxidative stress induced by Micrococcus luteus infection.
Peroxiredoxin 3 promotes IL-12 production from macrophages and partially protects mice against infection with Toxoplasma gondii.
Peroxiredoxin Asp f3 Is Essential for Aspergillus fumigatus To Overcome Iron Limitation during Infection.
Peroxiredoxin I protects gastric mucosa from oxidative injury induced by H. pylori infection.
Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK.
Peroxiredoxins from Trypanosoma cruzi: virulence factors and drug targets for treatment of Chagas disease?
Poplar peroxiredoxin Q. A thioredoxin-linked chloroplast antioxidant functional in pathogen defense.
Potential of recombinant 2-Cys peroxiredoxin protein as a vaccine for Fasciola gigantica infection.
PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.
Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice.
Proteomic analysis reveals differentially abundant proteins probably involved in the virulence of amastigote and promastigote forms of Leishmania infantum.
Proteomic Changes during MCMV Infection Revealed by iTRAQ Quantitative Proteomic Analysis in Maize.
Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses.
Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics.
Roles of alkyl hydroperoxide reductase subunit C (AhpC) in viable but nonculturable Vibrio parahaemolyticus.
S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection.
Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase.
Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway.
Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi.
Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase.
Use of in vivo induced technology to identify antigens expressed by Photobacterium damselae subsp. piscicida during infection of Senegalese sole (Solea senegalensis).
VACCINE-INDUCED PROTECTION AGAINST MURINE SCHISTOSOMIASIS MANSONI WITH LARVAL EXCRETORY-SECRETORY ANTIGENS AND PAPAIN OR TYPE-2 CYTOKINES.
Infertility
Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations.
Infertility, Male
Proteomics, oxidative stress and male infertility.
Influenza, Human
Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.
Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress.
The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins.
Insulin Resistance
Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation.
Peroxiredoxin 4 levels in patients with PCOS and/or obesity.
Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat.
Redox-Oligomeric State of Peroxiredoxin-2 and Glyceraldehyde-3-Phosphate Dehydrogenase in Obstructive Sleep Apnea Red Blood Cells under Positive Airway Pressure Therapy.
Insulinoma
Peroxiredoxin III protects pancreatic {beta} cells from apoptosis.
Intestinal Neoplasms
Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer.
Intestinal Volvulus
Molecular cloning of an enzymatically active thioredoxin peroxidase from Onchocerca volvulus.
Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites.
Iron Overload
Peroxiredoxin 5 prevents iron overload-induced neuronal death by inhibiting mitochondrial fragmentation and endoplasmic reticulum stress in mouse hippocampal HT-22 cells.
Irritable Bowel Syndrome
Association of Peroxiredoxin 1 and brain-derived neurotrophic factor serum levels with depression and anxiety symptoms in patients with irritable bowel syndrome.
Peroxiredoxin 1 as an inflammatory marker in diarrhea-predominant and postinfectious irritable bowel syndrome.
Ischemic Attack, Transient
Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage.
Comparison of the Immunoreactivity of Trx2/Prx3 Redox System in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia.
Ischemic Stroke
Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition.
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage.
Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke.
Keloid
Comparative proteomic analysis between normal skin and keloid scar.
Leishmaniasis
Cloning, expression and dynamic simulation of TRYP6 from Leishmania major (MRHO/IR/75/ER).
Dataset generated for Dissection of mechanisms of Trypanothione Reductase and Tryparedoxin Peroxidase through dynamic network analysis and simulations in leishmaniasis.
Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications.
Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence.
Molecular diagnosis of Old World leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp.
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Tryparedoxin peroxidase of Leishmania braziliensis: homology modeling and inhibitory effects of flavonoids for anti-leishmanial activity.
Leishmaniasis, Cutaneous
Molecular diagnosis of Old World leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp.
Leishmaniasis, Visceral
Antibodies against a Leishmania infantum peroxiredoxin as a possible marker for diagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment.
Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence.
Immunological consequences of stress-related proteins - cytosolic tryparedoxin peroxidase and chaperonin TCP20 - identified in splenic amastigotes of Leishmania donovani as Th1 stimulatory, in experimental visceral leishmaniasis.
Leukemia
Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells.
Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species.
Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities.
Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke.
Targeting peroxiredoxin I potentiates 1,25-dihydroxyvitamin D3-induced cell differentiation in leukemia cells.
The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia.
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2.
[Adenanthin Induces Differentiation of Acute Promyelocytic Leukemia Cells by Targeting Peroxiredoxin III].
Leukemia, B-Cell
Cytotoxicity and expression of genes involved in the cellular stress response and apoptosis in mammalian fibroblast exposed to cotton cellulose nanofibers.
Leukemia, Erythroblastic, Acute
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
The role of peroxiredoxin III on late stage of proerythrocyte differentiation.
Leukemia, Myeloid
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells.
Peroxiredoxin genes are not induced in myeloid leukemia cells exposed to ionizing radiation.
Leukemia, Myeloid, Acute
MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia.
PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22).
Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells.
Leukemia, Promyelocytic, Acute
Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species.
The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia.
[Adenanthin Induces Differentiation of Acute Promyelocytic Leukemia Cells by Targeting Peroxiredoxin III].
Leukoplakia, Oral
Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins.
Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia.
Proteome profiling to identify peroxiredoxin 1 interacting protein partners in nicotine-associated oral leukoplakia.
Lipoma
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Liver Abscess
Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess.
Liver Abscess, Amebic
Obtaining of three recombinant antigens of Entamoeba histolytica and evaluation of their immunogenic ability without adjuvant in a hamster model of immunoprotection.
Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess.
Liver Cirrhosis
Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma.
Liver Diseases
Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis.
Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.
Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS.
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Liver Failure
Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.
Liver Neoplasms
Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer.
Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line.
Peroxiredoxin 3 is resistant to oxidation-induced apoptosis of Hep-3b cells.
Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells.
Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells.
Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II.
[The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism]
Lung Diseases
Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates.
Lung Diseases, Interstitial
Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis.
Lung Neoplasms
An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib.
Augmented expression of peroxiredoxin I in lung cancer.
Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells.
Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer.
Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy.
Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung.
Glycoproteomic Analysis of Human Lung Adenocarcinomas Using Glycoarrays and Tandem Mass Spectrometry: Differential Expression and Glycosylation Patterns of Vimentin and Fetuin A Isoforms.
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Nuclear factor E2-related factor 2 dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer.
Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
PRDX4 and Its Roles in Various Cancers.
Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.
Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma.
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer.
Proteomic and genomic biomarkers for Non-Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha-1 antitrypsin.
Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex.
Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure.
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC.
S-nitrosylation of the Peroxiredoxin-2 promotes S-nitrosoglutathione-mediated lung cancer cells apoptosis via AMPK-SIRT1 pathway.
Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target.
Lupus Erythematosus, Systemic
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Lymphatic Metastasis
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Lymphocytic Choriomeningitis
Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells.
Lymphoma
Cisplatin induces apoptosis of A549 cells by downregulating peroxidase V.
Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.
Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas.
Novel endogenous negative modulators of platelet function as potential anti-thrombotic targets.
Lymphoma, B-Cell
Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells.
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Protective Effect of Fenofibrate on Oxidative Stress-Induced Apoptosis in Retinal-Choroidal Vascular Endothelial Cells: Implication for Diabetic Retinopathy Treatment.
Lymphoma, Follicular
Total peroxiredoxin expression is associated with survival in patients with follicular lymphoma.
Malaria
2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei.
A Genome-wide Chromatin-associated Nuclear Peroxiredoxin from the Malaria Parasite Plasmodium falciparum.
A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection.
Development of monoclonal antibodies against Plasmodium falciparum thioredoxin peroxidase 1 and its possible application for malaria diagnosis.
Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii.
Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum.
Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum.
Molecular cloning, characterization and expression profile of a glutathione peroxidase-like thioredoxin peroxidase (TPxGl) of the rodent malaria parasite Plasmodium berghei.
Peroxiredoxins in malaria parasites: parasitologic aspects.
Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites.
Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum.
Thioredoxin networks in the malarial parasite Plasmodium falciparum.
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum.
Measles
Peroxiredoxin 1 is required for efficient transcription and replication of measles virus.
Medulloblastoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3).
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors.
Melanoma
Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases.
Immunogenicity without immunoselection: a mutant but functional antioxidant enzyme retained in a human metastatic melanoma and targeted by CD8(+) T cells with a memory phenotype.
Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5.
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
Melioidosis
T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis.
Meningitis
A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease.
Mesothelioma, Malignant
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.
Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells.
Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells.
Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.
Metabolic Syndrome
Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan.
Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Peroxiredoxin 4 levels in patients with PCOS and/or obesity.
Migraine Disorders
[Herbs for calming liver and suppressing liver-yang in treatment of migraine with hyperactive liver-yang syndrome and its effects on lymphocyte protein expression: a randomized controlled trial]
Mouth Neoplasms
High-throughput screening of saliva for early detection of oral cancer: a pilot study.
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Multiple Myeloma
Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas.
The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death.
Multiple Sclerosis
Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation.
Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes.
Myasthenia Gravis
Increased serum peroxiredoxin 5 levels in myasthenia gravis.
Mycoses
A peroxiredoxin Q homolog from gentians is involved in both resistance against fungal disease and oxidative stress.
ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation.
Myocardial Infarction
Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice.
Peroxiredoxin2 (Prdx2) Reduces Oxidative Stress and Apoptosis of Myocardial Cells Induced by Acute Myocardial Infarction by Inhibiting the TLR4/Nuclear Factor kappa B (NF-?B) Signaling Pathway.
PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium.
Nasopharyngeal Carcinoma
Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma.
Neoplasm Metastasis
Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis.
Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis.
Comprehensive profiling of metastasis-related proteins in paired hepatocellular carcinoma cells with different metastasis potentials.
Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer.
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis.
Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice.
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the ?-catenin/ID2 pathway.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells.
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
PRDX4 and Its Roles in Various Cancers.
Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients.
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer.
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.
ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC.
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
The critical role of peroxiredoxin-2 in colon cancer stem cells.
Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer.
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
Neoplasms
2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I.
8-hydroxydeguanosine and nitrotyrosine are prognostic factors in urinary bladder carcinoma.
A PRDX1-p38? heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas.
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.
Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes.
AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy.
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I.
An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib.
Antisense of human peroxiredoxin II enhances radiation-induced cell death.
Augmented expression of peroxiredoxin I in lung cancer.
Autophagy sensitivity of neuroendocrine lung tumor cells.
Blue light activates phase 2 response proteins and slows growth of a431 epidermoid carcinoma xenografts.
c-Abl in oxidative stress, aging and cancer.
Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13.
Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms.
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells.
Comparative proteomic analysis between normal skin and keloid scar.
Comparative proteomic analysis of drug sodium iron chlorophyllin addition to Hep 3B cell line.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Conjugated linoleic acid synthesis-related protein proteasome subunit ? 5 (PSMA5) is increased by vaccenic acid treatment in goat mammary tissue.
Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha.
Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats.
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.
Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells.
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Downregulation of peroxiredoxin-1 by ?-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts.
Drug resistance to 5-FU linked to reactive oxygen species modulator 1.
Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII? as anti-tumor strategy.
Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I.
Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.
Elevated prx1 provides resistance to docetaxel, but is not associated with predictive significance in lung cancer.
Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer.
Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase.
Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas.
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer.
Expression and function of peroxiredoxins in gynecological malignancies.
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer.
Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy.
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung.
Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells.
Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation.
Expression of reactive species related genes is associated with patient survival in luminal B breast cancer.
Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.
Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues.
Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers.
FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function.
Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.
Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA.
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells.
Genetic Regulation of Redox Balance in ?-Thalassemia Trait.
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.
Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy.
Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro.
Human peroxiredoxin 1 modulates TGF-?1-induced epithelial-mesenchymal transition through its peroxidase activity.
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.
Hydrogen peroxide produced by Aplysia ink toxin kills tumor cells independent of apoptosis via peroxiredoxin I sensitive pathways.
Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis.
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Identification and verification of PRDX1 as an inflammation marker for colorectal cancer progression.
IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II.
Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis.
Identification of peroxiredoxin 6 as a potential lung-adenocarcinoma biomarker for predicting chemotherapy response by proteomic analysis.
Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis.
Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan.
Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.
Increased expression of peroxiredoxin II confers resistance to cisplatin.
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I.
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Investigation of peroxiredoxin IV as a calpain-regulated pathway in cancer.
Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells.
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis.
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.
Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.
Marginal zinc intake reduces the protective effect of lactation on mammary gland carcinogenesis in a DMBA-induced tumor model in mice.
MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells.
Mitochondrial Peroxiredoxin III is a Potential Target for Cancer Therapy.
Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State.
Momilactone sensitive proteins in Arabidopsis thaliana.
Multi-panel assay of serum autoantibodies in colorectal cancer.
Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I.
Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins.
Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions.
Novel roles of peroxiredoxins in inflammation, cancer and innate immunity.
Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level.
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma.
Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma.
Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer.
Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis.
Oxidation of 2-Cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2.
Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis.
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway.
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Peroxiredoxin 1 - an antioxidant enzyme in cancer.
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.
Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy.
Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4.
Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia.
Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia.
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer.
Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation.
Peroxiredoxin 4: a novel secreted mediator of cancer induced osteoclastogenesis.
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma.
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Peroxiredoxin I expression in human thyroid tumors.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells.
Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells.
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers.
Peroxiredoxin II Restrains DNA Damage-induced Death in Cancer Cells by Positively Regulating JNK-dependent DNA Repair.
Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid.
Peroxiredoxin Involvement in the Initiation and Progression of Human Cancer.
Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.
Peroxiredoxin V Reduces ?-Lapachone-induced Apoptosis of Colon Cancer Cells.
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Peroxiredoxin V: A candidate breast tumor marker of population specificity.
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer.
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.
Peroxiredoxin2 downregulation enhances hepatocellular carcinoma proliferation and migration, and is associated with unfavorable prognosis in patients.
Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.
Peroxiredoxins and antioxidant enzymes in pilocytic astrocytomas.
Peroxiredoxins in breast carcinoma.
Peroxiredoxins, a novel protein family in lung cancer.
Peroxiredoxins, gerontogenes linking aging to genome instability and cancer.
Piecing Together How Peroxiredoxins Maintain Genomic Stability.
PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase.
PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium.
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells.
Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells.
PRDX4 and Its Roles in Various Cancers.
PRDX4 overexpression is associated with poor prognosis in gastric cancer.
PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress.
Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.
Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I.
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer.
Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma.
Prognostic Value of Peroxiredoxin-1 Expression in Patients with Solid Tumors: a Meta-Analysis of Cohort Study.
Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells.
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II.
Proteomic analysis of psoriatic skin tissue for identification of differentially expressed proteins: Up-regulation of GSTP1, SFN and PRDX2 in psoriatic skin.
Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.
Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.
Proteomics-based approach identifying autoantibody against peroxiredoxin VI as a novel serum marker in esophageal squamous cell carcinoma.
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug.
Prx2 links ROS homeostasis to stemness of cancer stem cells.
Re: Peroxiredoxin 4: A Novel Secreted Mediator of Cancer Induced Osteoclastogenesis.
Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure.
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.
Role of peroxiredoxin I in rectal cancer and related to p53 status.
ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC.
SF2523 inhibits human chondrosarcoma cell growth in vitro and in vivo.
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
Small interfering RNA targeting of peroxiredoxin? gene enhances formaldehyde-induced toxicity in bone marrow cells isolated from BALB/c mice.
Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors.
Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.
Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.
Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death.
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents.
The Combination Of Weak Expression Of PRDX4 And Very High MIB-1 Labelling Index Independently Predicts Shorter Disease-free Survival In Stage I Lung Adenocarcinoma.
The critical role of peroxiredoxin-2 in colon cancer stem cells.
The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions.
The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells.
The Role of Peroxiredoxin Family in Cancer Signaling.
The role of peroxiredoxin II in chemoresistance of breast cancer cells.
The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells.
The Role of Redox-Regulating Enzymes in Inoperable Breast Cancers Treated with Neoadjuvant Chemotherapy.
The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
The tumor suppressor mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
Threonine modulates immune response, antioxidant status and gene expressions of antioxidant enzymes and antioxidant-immune-cytokine-related signaling molecules in juvenile blunt snout bream (Megalobrama amblycephala).
Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.
Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration.
Upregulation of Peroxiredoxin-2 in Well-Differentiated Pancreatic Neuroendocrine Tumors and Its Utility as a Biomarker for Predicting the Response to Everolimus.
Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells.
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors.
[Ascites May Provide Useful Information for Diagnosis of Ovarian Cancer].
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
[Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma]
[The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism]
Nervous System Diseases
Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms.
The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders.
Neuroblastoma
Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease.
Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains.
Peroxiredoxin I regulates the component expression of ?-secretase complex causing the Alzheimer's disease.
Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP(+).
The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
Neurodegenerative Diseases
Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.
Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
Peroxiredoxin 2 is involved in the neuroprotective effects of PACAP in cultured cerebellar granule neurons.
Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders.
Posttranslational modification of cysteine in redox signaling and oxidative stress: focus on s-glutathionylation.
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Neuroinflammatory Diseases
Modulation of vascular integrity and neuroinflammation by peroxiredoxin 4 following cerebral ischemia-reperfusion injury.
Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-?B-mediated iNOS induction and microglial activation.
Non-alcoholic Fatty Liver Disease
Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL.
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Obesity
Author Correction: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity.
Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure.
Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats.
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Peroxiredoxin 4 levels in patients with PCOS and/or obesity.
Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat.
Obesity, Abdominal
Peroxiredoxin 4 levels in patients with PCOS and/or obesity.
Opisthorchiasis
Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis.
Osteoarthritis
Expression and regulation of peroxiredoxin 5 in human osteoarthritis.
Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model.
Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.
The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy.
Osteosarcoma
?-Elemene Enhances the Sensitivity of Osteosarcoma Cells to Doxorubicin via Downregulation of Peroxiredoxin-1.
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics.
Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment.
Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells.
Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma.
Ototoxicity
The role of peroxiredoxin I in cisplatin-induced ototoxicity.
Out-of-Hospital Cardiac Arrest
The Combination of Biomarkers for Prognostication of Long-Term Outcome in Patients Treated with Mild Hypothermia After Out-of-Hospital Cardiac Arrest-A Pilot Study.
Ovarian Neoplasms
CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.
Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer.
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer.
Peroxiredoxin-1 as a prognostic factor in patients with ovarian cancer.
PRDX4 and Its Roles in Various Cancers.
Proteomic analysis of ovarian cancer proximal fluids: validation of elevated peroxiredoxin 1 in patient peripheral circulation.
The prognostic values of the peroxiredoxins family in ovarian cancer.
Pancreatic Neoplasms
Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue.
Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer.
Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity.
Peroxiredoxin 1 silencing inhibited the growth and promoted apoptosis of pancreatic cancer cells via targeting FOXO3 gene.
Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells.
Pancreatitis
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Papillomavirus Infections
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Parasitemia
Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi.
Parasitic Diseases
A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection.
Paratuberculosis
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Parkinson Disease
Oxidative Modification of Peroxiredoxin Is Associated with Drug-induced Apoptotic Signaling in Experimental Models of Parkinson Disease.
Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: impact on Parkinson's disease.
Proteomic Profiling of the Insoluble Pellets of the Transected Rat Spinal Cord.
S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease.
Parkinsonian Disorders
Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism.
Peptic Ulcer
Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity.
Periodontitis
Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway.
Persistent Infection
Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence.
Plasmablastic Lymphoma
Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas.
Pneumonia
Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I.
Evolution and function of the Mycoplasma hyopneumoniae peroxiredoxin, a 2-Cys-like enzyme with a single Cys residue.
Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.
Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure.
Peroxiredoxin v contributes to antioxidant defense of lung epithelial cells.
The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis.
Polycystic Ovary Syndrome
Downregulated Expression of Peroxiredoxin 4 in Granulosa Cells from Polycystic Ovary Syndrome.
Peroxiredoxin 4 levels in patients with PCOS and/or obesity.
Plasma level of peroxiredoxin 3 in patients with polycystic ovarian syndrome.
Pre-Eclampsia
Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells.
Prediabetic State
Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Premature Birth
Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates.
Prostatic Hyperplasia
Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation.
Prostatic Intraepithelial Neoplasia
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.
Prostatic Neoplasms
Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer.
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.
Peroxiredoxin 2 in the nucleus and cytoplasm distinctly regulates androgen receptor activity in prostate cancer cells.
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.
PRDX4 and Its Roles in Various Cancers.
The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells.
Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration.
protein kinase c deficiency
Loss of PKC-delta alters cardiac metabolism.
Pseudorabies
Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
Psoriasis
Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis.
Pterygium
Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium.
Overexpression of peroxiredoxin 2 in pterygium. A proteomic approach.
Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage.
Proteomic analysis in pterygium; upregulated protein expression of ALDH3A1, PDIA3, and PRDX2.
Pulmonary Disease, Chronic Obstructive
Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis.
Susceptibility to COPD: differential proteomic profiling after acute smoking.
Pulmonary Fibrosis
Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I.
[Expression of peroxiredoxin I in the rats exposed to silica].
Rabies
Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses.
Rectal Neoplasms
Role of peroxiredoxin I in rectal cancer and related to p53 status.
Renal Insufficiency, Chronic
Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.
Reperfusion Injury
Increased expression of peroxiredoxin 1 and identification of a novel lipid-metabolizing enzyme in the early phase of liver ischemia reperfusion injury.
Modulation of vascular integrity and neuroinflammation by peroxiredoxin 4 following cerebral ischemia-reperfusion injury.
Retinal Detachment
Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits.
Rhabdomyoma
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Rheumatic Diseases
[Investigation of the spreading of rheumatic disease; incidence of rheumatic disease in the members of a Bus and Streetcar Society of Torin; clinical & radiological findings.]
Sarcoidosis
A Novel Sarcoidosis Risk Locus for Europeans on Chromosome 11q13.1.
A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease.
Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study.
Sarcoma, Ewing
Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma.
Sarcoma, Kaposi
Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells.
Scabies
Characterisation and analysis of thioredoxin peroxidase as a potential antigen for the serodiagnosis of sarcoptic mange in rabbits by dot-ELISA.
Schistosomiasis
Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni.
Schistosomiasis mansoni
Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation.
Scleroderma, Systemic
Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress.
Scurvy
The role of ascorbate in protein folding.
Sepsis
A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease.
Circulating levels of Peroxiredoxin 4 as a Novel Biomarker of Oxidative Stress in Patients with Sepsis.
Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137.
Sulfiredoxin Protects Mice from Lipopolysaccharide-Induced Endotoxic Shock.
Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice.
Severe Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Shock, Cardiogenic
Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach.
Shock, Septic
Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation.
Silicosis
[Differential expression of PRDX4 in alveolar macrophages of patients with silicosis].
Skin Neoplasms
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Spinal Cord Injuries
Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats.
Squamous Cell Carcinoma of Head and Neck
Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma.
Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma.
Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum].
Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma.
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus.
Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions.
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Starvation
A proteome analysis of the tetracyanonickelate (II) responses in Klebsiella oxytoca.
Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex.
Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.
Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.
The cytidine repressor regulates the survival of Pantoea agglomerans YS19 under oxidative stress and sulfur starvation conditions.
The response of Cupriavidus metallidurans CH34 to spaceflight in the international space station.
Stillbirth
Crucial role of peroxiredoxin III in placental antioxidant defense of mice.
Stomach Neoplasms
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells.
CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability.
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Inhibition of peroxiredoxin 2 suppresses Wnt/?-catenin signaling in gastric cancer.
Peroxiredoxin 5 overexpression enhances tumorigenicity and correlates with poor prognosis in gastric cancer.
Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.
Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells.
Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor b signaling pathway.
RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells.
Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer.
Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells.
Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death.
Systematic Characterization of Prognostic Values of Peroxiredoxin Family in Gastric Cancer.
[New early gastric cancer marker PRDX4 promote the tumorigenesis and progression of gastric cancer via eliminating ROS].
Stroke
Brain Extracellular Fluid Protein Changes in Acute Stroke Patients.
Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction.
Different effects of arginine vasopressin on high-mobility group box 1 expression in astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms.
Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats.
Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke.
Peroxiredoxin sets the brain on fire after stroke.
Subarachnoid Hemorrhage
Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage.
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage.
Systemic Vasculitis
Peroxiredoxin 2 is a novel autoantigen for anti-endothelial cell antibodies in systemic vasculitis.
Tachycardia, Ventricular
[Experiences with the new cardioverter-defibrillator Ventak PRxII]
Tauopathies
Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis.
Teratoma
Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells.
Thalassemia
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in ?-Thalassemic Erythropoiesis.
thioredoxin-dependent peroxiredoxin deficiency
Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells.
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.
Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice.
Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.
Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells.
Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus.
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Peroxiredoxin I deficiency increases LPS?induced lethal shock in mice.
Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-?B-mediated iNOS induction and microglial activation.
Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.
Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells.
Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable.
Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice.
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Thrombosis
Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.
[Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma]
Thymoma
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Thyroid Neoplasms
Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells.
Thyroiditis
Peroxiredoxin I expression in human thyroid tumors.
Tongue Neoplasms
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Toxoplasmosis
Evaluation of toxoplasmosis in pregnant women using dot-immunogold-silver staining with recombinant Toxoplasma gondii peroxiredoxin protein.
Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice.
Triple Negative Breast Neoplasms
Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells.
Tuberculosis
Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis.
An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis.
Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila.
Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin.
Disruption of redox catalytic functions of peroxiredoxin-thioredoxin complex in Mycobacterium tuberculosis H37Rv using small interface binding molecules.
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis.
Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages.
Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress.
Kinetics of formation and reactivity of the persulfide in the one-cysteine peroxiredoxin from Mycobacterium tuberculosis.
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
Multiscale Modeling of Thiol Overoxidation in Peroxiredoxins by Hydrogen Peroxide.
Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.
Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.
Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis.
Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation.
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures.
PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase.
Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis.
Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation.
Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C.
The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin.
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics.
[Mechanisms of drug-resistance in mycobacteria]
[Multidrug-resistant tuberculosis. 2. Mechanisms of drug-resistance in Mycobacterium tuberculosis--genetic mechanisms of drug-resistance]
Tuberous Sclerosis
IL-4 up-regulates cyclooxygenase-1 expression in macrophages.
Tularemia
Role of peroxiredoxin of the AhpC/TSA family in antioxidant defense mechanisms of Francisella tularensis.
Urinary Bladder Neoplasms
Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer.
Screening of Differentially Expressed Genes Related to Bladder Cancer and Functional Analysis with DNA Microarray.
Uterine Cervical Neoplasms
Anti-apoptotic role of peroxiredoxin III in cervical cancer cells.
Differential proteins among normal cervix cells and cervical cancer cells with HPV-16 infection, through mass spectrometry-based Proteomics (2D-DIGE) in women from Southern México.
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.
Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer.
Proteomic Identification of Neoadjuvant Chemotherapy-Related Proteins in Bulky Stage IB-IIA Squamous Cervical Cancer.
Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer.
[Expression of peroxiredoxin III cervical lesions]
Vaccinia
A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis.
Heterologous priming-boosting with DNA and modified vaccinia virus Ankara expressing tryparedoxin peroxidase promotes long-term memory against Leishmania major in susceptible BALB/c Mice.
IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection.
Selection of appropriate serological tests to measure the incidence of natural Leishmania infantum infection during DNA/MVA prime/boost canine vaccine trials.
Varicocele
Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response.
Vascular Diseases
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Vascular System Injuries
Vascular Injury Involves the Overoxidation of Peroxiredoxin Type II and Is Recovered by the Peroxiredoxin Activity Mimetic That Induces Reendothelialization.
Vasculitis
A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease.
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease.
Virus Diseases
Characterization of a silkworm thioredoxin peroxidase that is induced by external temperature stimulus and viral infection.
Molecular characterization, immune response against white spot syndrome virus infection of peroxiredoxin 4 in Fenneropenaeus chinensis and its antioxidant activity.
Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells.
The Human Cytomegalovirus Protein pUL38 Suppresses Endoplasmic Reticulum Stress-Mediated Cell Death Independently of Its Ability To Induce mTORC1 Activation.