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Information on EC 1.11.1.20 - prostamide/prostaglandin F2alpha synthase
for references in articles please use BRENDA:EC1.11.1.20
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EC Tree 1 Oxidoreductases
1.11 Acting on a peroxide as acceptor
1.11.1 Peroxidases
1.11.1.20 prostamide/prostaglandin F2alpha synthase
IUBMB Comments
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2α. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
pm/pgfs, prostamide f synthase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
prostamide F synthase
prostamide/PGF synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
arachidonate metabolites biosynthesis, C20 prostanoid biosynthesis, di-homo-gamma-linolenate metabolites biosynthesis, icosapentaenoate metabolites biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prostaglandin H2 + reduced thioredoxin
prostaglandin F2alpha + oxidized thioredoxin
-
Substrates: -
Products: -
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?
prostamide F2alpha + oxidized thioredoxin
prostamide H2 + reduced thioredoxin
-
Substrates: -
Products: -
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?
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
thioredoxin + cumene hydroperoxide
thioredoxin disulfide + ?
Substrates: -
Products: -
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?
thioredoxin + cumene hydroperoxide
thioredoxin disulfide + H2O + 2-phenylpropan-2-ol
Substrates: -
Products: -
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?
thioredoxin + H2O2
thioredoxin disulfide + 2 H2O
Substrates: -
Products: -
Products: -
?
thioredoxin + t-butyl hydroperoxide
thioredoxin disulfide + ?
Substrates: -
Products: -
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?
thioredoxin + tert-butyl hydroperoxide
thioredoxin disulfide + H2O + tert-butanol
Substrates: -
Products: -
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?
prostamide H2 + reduced thioredoxin
prostamide F2alpha + oxidized thioredoxin
-
Substrates: -
Products: -
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?
prostamide H2 + reduced thioredoxin
prostamide F2alpha + oxidized thioredoxin
-
Substrates: -
Products: -
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?
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
-
Substrates: (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
?
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
Substrates: (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. Prostaglandin H2 and prostamide H2 are the best substrates
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
?
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
Substrates: (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
-
Substrates: (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
Substrates: (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. Prostaglandin H2 and prostamide H2 are the best substrates. Cys44 is essential for the catalytic activity of prostamide/PGF synthase
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
-
Substrates: i.e. prostamide H2
Products: -
Products: -
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
Substrates: (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. grostaglandin H2
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
?
thioredoxin + prostaglandin H2
thioredoxin disulfide + prostaglandin F2alpha
-
Substrates: -
Products: -
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?
thioredoxin + prostaglandin H2
thioredoxin disulfide + prostaglandin F2alpha
Substrates: prostaglandin H2 is one of the best substrates
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?
thioredoxin + prostamide H2
thioredoxin disulfide + prostamide F2alpha
-
Substrates: -
Products: -
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?
thioredoxin + prostamide H2
thioredoxin disulfide + prostamide F2alpha
Substrates: prostamide H2 is one of the best substrates
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?
additional information
?
-
Substrates: prostaglandin D2 and prostaglandin E2 are not reduced
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?
additional information
?
-
-
Substrates: prostaglandin D2 and prostaglandin E2 are not reduced
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?
additional information
?
-
Substrates: neither prostaglandin E2 nor prostamide D2 serve as a substrate even at the concentration of 1.5 mM
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?
additional information
?
-
-
Substrates: neither prostaglandin E2 nor prostamide D2 serve as a substrate even at the concentration of 1.5 mM
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?
additional information
?
-
Substrates: the recombinant enzyme requires thioredoxin as a reducing equivalent donor more efficiently than NADPH, NADH, or GSH
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?
additional information
?
-
-
Substrates: the recombinant enzyme requires thioredoxin as a reducing equivalent donor more efficiently than NADPH, NADH, or GSH
Products: -
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prostaglandin H2 + reduced thioredoxin
prostaglandin F2alpha + oxidized thioredoxin
-
Substrates: -
Products: -
Products: -
?
prostamide F2alpha + oxidized thioredoxin
prostamide H2 + reduced thioredoxin
-
Substrates: -
Products: -
Products: -
?
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
-
Substrates: (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
thioredoxin + prostaglandin H2
thioredoxin disulfide + prostaglandin F2alpha
-
Substrates: -
Products: -
Products: -
?
thioredoxin + prostamide H2
thioredoxin disulfide + prostamide F2alpha
-
Substrates: -
Products: -
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?
prostamide H2 + reduced thioredoxin
prostamide F2alpha + oxidized thioredoxin
-
Substrates: -
Products: -
Products: -
?
prostamide H2 + reduced thioredoxin
prostamide F2alpha + oxidized thioredoxin
-
Substrates: -
Products: -
Products: -
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
-
Substrates: (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
Products: (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
?
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
-
Substrates: i.e. prostamide H2
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
cumene hydroperoxide
competitive inhibition of prostamide F synthase activity
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ammonium sulfate
the activity of the purified recombinant enzyme is stimulated about 4fold by 1.5 M ammonium sulfate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0076 - 0.014
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
0.0076
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
pH 7.0, 24°C, i.e. prostamide H2
0.014
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
i.e. prostamide H2, pH 7.0, 24°C
0.0069
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
pH 7.0, 24°C, i.e. prostaglandin H2
0.007
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
i.e. prostaglandin H2, pH 7.0, 24°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.09
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
pH 7.0, 24°C, i.e. prostamide H2
0.25
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
pH 7.0, 24°C, i.e. prostaglandin H2
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.25
0.28
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 8
pH 6.5: about 50% of maximal activity, pH 8.0: about 70% of maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
24
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
-
the enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies. The enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons. At the ultrastructural level, the enzyme is localized to myelin sheaths. Expression of the enzyme increases between postnatal day 9 and postnatal day 14 during the postnatal development, presumably in accordance with myelinogenesis
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
-
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
localized in the superficial layer of the dorsal horn, in motor neurons of the ventral horn, and in glia of the white matter of the spinal cord. Activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs
brenda
-
there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
brenda
-
the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
the elevation of intraocular pressure caused by deletion of the enzyme gene likely results from a diversion of the endoperoxide precursor pathway to provide increased levels of those prostanoids known to raise intraocular pressure, namely prostaglandin D2 and thromboxane A2
physiological function
physiological function
-
prostaglandin ethanolamide, i.e. prostamide, F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide (anandamide) that induces pharmacological actions in ocular tissues. Prostamide/PGF synthase catalyzes the reductions of prostamide H2 to prostamide F2alpha and PGH2 to PGF2alpha, chiefly in the central nervous system
physiological function
-
the enzyme serves an important regulatory role in the eye by providing prostaglandin F2alpha and prostamide F2alpha to constrain the influence of those prostanoids that raise intraocular pressure
Show AA Sequence and Transmembrane Helices (665 entries)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
20000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
x * 21670, stimulation by ammonium sulfate suggests that the enzyme may be a dimer or oligomer instead of a monomer, calculated from sequence
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C44S
C44S/C47S
C47S
C44S
the mutant is almost inactive with less than 1% of wild type activity
C44S/C47S
the mutant is almost inactive with less than 1% of wild type activity
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
construction of an expression plasmid using polyhistidine-tagged peptide-fused vector and mouse cDNA encoding a 201-amino acid polypeptide with molecular weight of 21669 Da and expression the protein in Escherichia coli
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moriuchi, H.; Koda, N.; Okuda-Ashitaka, E.; Daiyasu, H.; Ogasawara, K.; Toh, H.; Ito, S.; Woodward, D.F.; Watanabe, K.
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily
J. Biol. Chem.
283
792-801
2008
Mus musculus (Q9DB60), Mus musculus, Sus scrofa (A9CQL8), Sus scrofa
brenda
Yoshikawa, K.; Takei, S.; Hasegawa-Ishii, S.; Chiba, Y.; Furukawa, A.; Kawamura, N.; Hosokawa, M.; Woodward, D.F.; Watanabe, K.; Shimada, A.
Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system
Brain Res.
1367
22-32
2011
Mus musculus
brenda
Urquhart, P.; Nicolaou, A.; Woodward, D.
Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases
Biochim. Biophys. Acta
1851
366-376
2015
Rattus norvegicus
brenda
Silvestri, C.; Martella, A.; Poloso, N.J.; Piscitelli, F.; Capasso, R.; Izzo, A.; Woodward, D.F.; Di Marzo, V.
Anandamide-derived prostamide F2alpha negatively regulates adipogenesis
J. Biol. Chem.
288
23307-23321
2013
Mus musculus
brenda
Woodward, D.F.; Wang, J.W.; Poloso, N.J.
Recent progress in prostaglandin F2alpha ethanolamide (prostamide F2alpha) research and therapeutics
Pharmacol. Rev.
65
1135-1147
2013
Mus musculus
brenda
Iwasa, K.; Yamamoto, S.; Takahashi, M.; Suzuki, S.; Yagishita, S.; Awaji, T.; Maruyama, K.; Yoshikawa, K.
Prostaglandin F2alpha FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model
Prostaglandins Leukot. Essent. Fatty Acids
91
175-182
2014
Mus musculus
brenda
Bertrand, J.A.; Woodward, D.F.; Sherwood, J.M.; Spenlehauer, A.; Silvestri, C.; Piscitelli, F.; Marzo, V.D.; Yamazaki, M.; Sakimura, K.; Inoue, Y.; Watanabe, K.; Overby, D.R.
Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure
Prostaglandins Leukot. Essent. Fatty Acids
165
102235
2021
Mus musculus
brenda
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