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Information on EC 1.10.3.5 - 3-hydroxyanthranilate oxidase
for references in articles please use BRENDA:EC1.10.3.5
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EC Tree 1 Oxidoreductases
1.10 Acting on diphenols and related substances as donors
1.10.3 With oxygen as acceptor
1.10.3.5 3-hydroxyanthranilate oxidase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 1.10.3.5
-
quinolinic
-
excitotoxin
-
quin
- convulsion
- kynureninase
-
neurotoxin
- indoleamine
-
phosphoribosyltransferase
-
3,4-dioxygenase
-
hyperbaric
- medicine
Reaction Schemes
showSynonyms
3hao, 3-hydroxyanthranilic acid dioxygenase, 3-hydroxyanthranilic acid oxidase, 3-hydroxyanthranilate oxidase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-hydroxyanthranilic acid oxidase
-
-
-
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3HAO
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
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redox reaction
-
-
-
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reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
3-hydroxyanthranilate:oxygen oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
37256-53-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
additional information
?
-
-
Substrates: 2-amino-3-hydroxytoluene is no substrate
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
3-hydroxy-4-methylanthranilic acid + O2
actinocin
-
Substrates: -
Products: -
Products: -
?
3-hydroxy-4-methylanthranilic acid + O2
actinocin
-
Substrates: -
Products: -
Products: -
?
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
-
Substrates: -
Products: -
Products: -
?
3-hydroxy-L-kynurenine + O2
(2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
-
Substrates: -
Products: -
Products: -
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
-
Substrates: -
Products: cinnabarinic acid, oxidative dimerization
Products: cinnabarinic acid, oxidative dimerization
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
-
Substrates: -
Products: cinnabarinic acid, oxidative dimerization
Products: cinnabarinic acid, oxidative dimerization
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
-
Substrates: -
Products: cinnabarinic acid, oxidative dimerization
Products: cinnabarinic acid, oxidative dimerization
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 3-hydroxyanthranilic acid + 2 O2
2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
Substrates: -
Products: -
Products: -
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
-
Substrates: -
Products: cinnabarinic acid, oxidative dimerization
Products: cinnabarinic acid, oxidative dimerization
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
-
Substrates: -
Products: cinnabarinic acid, oxidative dimerization
Products: cinnabarinic acid, oxidative dimerization
?
3-hydroxyanthranilic acid + O2
2-amino-2H-isophenoxazine-3-one-1,9-dicarboxylic acid + H2O2
-
Substrates: -
Products: cinnabarinic acid, oxidative dimerization
Products: cinnabarinic acid, oxidative dimerization
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Fe2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Leukemia
[Tryptophan conversion to nicotinic acid in mice with Friend's leukemia. I. 3-Hydroxyanthranilic acid oxidase activity.]
Pellagra
Tryptophan metabolism in alcoholic pellagra patients: measurements of urinary metabolites and histochemical studies of related muscle enzymes.
Seizures
Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
enzyme activity increases in the brains of Huntington disease victims
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morgan, L.R.; Weimorts, D.M.; Aubert, C.C.
Oxidation of 3-hydroxyanthranilic acid by a soluble liver fraction from poikilothermic vertebrates
Biochim. Biophys. Acta
100
393-402
1965
Alligator mississippiensis, Amphiuma means, Chelydra serpentina, Felis catus, Pseudemys concinna floridana, Rattus norvegicus, Rhinella marina, Streptomyces antibioticus, Terrapene carolina, Trachemys scripta
brenda
Nair, P.M.
Regulation of nuclear 3-hydroxyanthranilic acid oxidase by guanine
Arch. Biochem. Biophys.
153
139-146
1972
Gallus sp., Mus musculus, Ovis aries, Rattus norvegicus, Spinacia oleracea, Streptomyces antibioticus, Trametes coccinea
brenda
Parli, C.J.; Krieter, P.; Schmidt, B.
Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: a potent inhibitor of 3-hydroxyanthranilic acid oxidase
Arch. Biochem. Biophys.
203
161-166
1980
Cavia porcellus, Rattus norvegicus, Rattus norvegicus Wistar
brenda
Cook, J.S.; Pogson, C.I.
Tryptophan and glucose metabolism in rat liver cells. The effects of DL-6-chlorotryptophan, 4-chloro-3-hydroxyanthranilate and pyrazinamide
Biochem. J.
214
511-516
1983
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Brown, O.R.; Draczynska-Lusiak, B.
Oxygen activation and inactivation of quinolinate-producing and iron-requiring 3-hydroxyanthranilic acid oxidase: A role in hyperbaric oxygen-induced convulsions?
Redox Rep.
1
383-385
1995
Homo sapiens, Rattus norvegicus
brenda
Dang, Y.; Xia, C.; Brown, O.R.
Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway
Free Radic. Biol. Med.
25
1033-1043
1998
Bos taurus, Felis catus, Homo sapiens, Oncorhynchus mykiss, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
EXTERNAL LINKS (specific for EC-Number 1.10.3.5)
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