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EC unknown
Reaction Schemes
(R)-littorine
+
=
hyoscyamine aldehyde
+
Synonyms
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(R)-littorine + acceptor = hyoscyamine aldehyde + reduced acceptor
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(R)-littorine:acceptor oxidoreductase
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(R)-littorine + acceptor
3'-hydroxylittorine + reduced acceptor
Substrates: expression in yeast confirms that CYP80F1 catalyzes the oxidation of (R)-littorine with rearrangement to form hyoscyamine aldehyde, a putative precursor to hyoscyamine, and without rearrangement to form 3'-hydroxylittorine
?
(R)-littorine + acceptor
hyoscyamine aldehyde + reduced acceptor
Substrates: expression in yeast confirms that CYP80F1 catalyzes the oxidation of (R)-littorine with rearrangement to form hyoscyamine aldehyde, a putative precursor to hyoscyamine, and without rearrangement to form 3'-hydroxylittorine
?
(S)-littorine + acceptor
(2'S,3'S)-3'-hydroxylittorine + (2'S,3'R)-3'-hydroxylittorine + ?
Substrates: products are (2'S,3'S)-3'-hydroxylittorine, and a minor amount of (2'S,3'R)-3'-hydroxylittorine
?
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additional information
production of the corresponding compounds was found to be dependent on NADPH, but not NADH
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UniProt
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root-specific expression
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Highest Expressing Human Cell Lines
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Gene Links
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malfunction
silencing CYP80F1 results in reduced hyoscyamine levels and the accumulation of littorine
physiological function
involvement of the enzyme (CYP80F1) in the tropane alkaloid pathway, in the rearrangement of littorine to hyoscyamine
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Q1A1B0_HYONI
510
0
58648
TrEMBL
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expression in yeast. CYP80F1 ORF is cloned into the vector pMDC32 and is used to generate Nicotiana tabacum hairy root cultures. Hyoscyamus niger hairy root cultures are generated in which CYP80F1 is overexpressed
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Li, R.; Reed, D.W.; Liu, E.; Nowak, J.; Pelcher, L.E.; Page, J.E.; Covello, P.S.
Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement
Chem. Biol.
13
513-520
2006
Hyoscyamus niger (Q1A1B0)
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