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Information on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)

for references in articles please use BRENDA:EC1.1.99.37

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IUBMB Comments

Contains Zn2+ and Mg2+. Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis [1-3]. These enzymes are decameric, and possess a 5-fold symmetry . Some of the enzymes can also dismutate formaldehyde to methanol and formate .

The enzyme appears in viruses and cellular organisms

Synonyms
ndma-dependent methanol dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
methanol + acceptor = formaldehyde + reduced acceptor
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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