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Information on EC 1.1.99.30 - 2-oxo-acid reductase

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IUBMB Comments
Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.
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The expected taxonomic range for this enzyme is: Proteus
Synonyms
(2R)-hydroxycarboxlate viologen oxidoreductase, (2R)-hydroxycarboxlate-viologen-oxidoreductase, (2R)-hydroxycarboxylate-viologen-oxidoreductase, 2-oxoacid reductase, D-2-hydroxy acid dehydrogenase, dehydrogenase, D-2-hydroxy acid, HVOR, hydroxy carboxylate viologen oxidoreductase, hydroxycarboxlate-oxidoreductase, hydroxycarboxlate-viologen-oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor
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