Information on EC 1.1.98.3 - decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.98 With other, known, physiological acceptors 1.1.98.3 decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase

IUBMB Comments

The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.1.333, decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-β-D-ribofuranose to trans,octacis-decaprenylphospho-β-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.

The enzyme appears in viruses and cellular organisms

1.1.98.3
tuberculosis
mycobacterium
antitubercular
benzothiazinones
antimycobacterial
antituberculosis
pbtz169
arabinans
arabinogalactan
anti-tb
corynebacterineae
drug-susceptible
xdr-tb
1,2,3-triazole
tca1
dinitrobenzamides
nitroso
analysis

Reaction Schemes

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trans,octacis-decaprenylphospho-beta-D-ribofuranose

FAD

trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose

FADH2

Synonyms
dpre1, rv3790, decaprenylphosphoryl-beta-d-ribose 2'-epimerase, decaprenylphosphoryl-d-ribose oxidase, decaprenylphospho-beta-d-ribofuranose 2-oxidase, msmeg_6382, decaprenylphosphoryl-beta-d-ribose 2-epimerase, more