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Information on EC 1.1.5.2 - glucose 1-dehydrogenase (PQQ, quinone) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.1.5.2

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IUBMB Comments

Integral membrane protein containing PQQ as a cofactor. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
pqqgdh, quinoprotein glucose dehydrogenase, m-gdh, pqq-gdh, membrane-bound glucose dehydrogenase, pyrroloquinoline quinone-dependent glucose dehydrogenase, pqq-dependent glucose dehydrogenase, soluble glucose dehydrogenase, gdh-b, pqqgdh-b, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase
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dehydrogenase, glucose (pyrroloquinoline-quinone)
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glucose dehydrogenase
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glucose dehydrogenase (PQQ dependent)
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glucose dehydrogenase (pyrroloquinoline-quinone)
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PQQGDH
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quinoprotein D-glucose dehydrogenase
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quinoprotein glucose dehydrogenase
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quinoprotein glucose DH
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
MetaCyc
glucose and glucose-1-phosphate degradation, glucose degradation (oxidative), L-ascorbate biosynthesis VIII (engineered pathway)
SYSTEMATIC NAME
IUBMB Comments
D-glucose:ubiquinone oxidoreductase
Integral membrane protein containing PQQ as a cofactor. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.
CAS REGISTRY NUMBER
COMMENTARY hide
81669-60-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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Substrates: -
Products: -
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyrroloquinoline quinone
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.037
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cells grown on a phosphate-sufficient minimal medium M9
0.058
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cells grown on a phosphate-deficient medium TRP
top print hide Go to Organism Search
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
top print hide Go to Localization Search
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
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apoenzyme is used as a biological test system for the detection of very low amounts of pyrroloquinoline quinone
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duine, J.A.; Frank, J.; Jongejan, J.A.
Detection and determination of pyrroloquinoline quinone, the coenzyme of quinoproteins
Anal. Biochem.
133
239-243
1983
Pseudomonas aeruginosa, Klebsiella aerogenes
Manually annotated by BRENDA team
Matsushita, K.; Shinagawa, E.; Inoue, T.; Adachi, O.; Ameyama, M.
Immunological evidence for two types of PQQ-dependent D-glucose dehydrogenase in bacterial membranes and the location of the enzyme in Escherichia coli
FEMS Microbiol. Lett.
37
141-144
1986
Acinetobacter calcoaceticus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Gluconobacter oxydans, Acetobacter aceti
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Manually annotated by BRENDA team
Buch, A.; Archana, G.; Naresh Kumar, G.
Metabolic channeling of glucose towards gluconate in phosphate-solubilizing Pseudomonas aeruginosa P4 under phosphorus deficiency
Res. Microbiol.
159
635-642
2008
Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas aeruginosa P4
Manually annotated by BRENDA team