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Information on EC 1.1.5.2 - glucose 1-dehydrogenase (PQQ, quinone)

for references in articles please use BRENDA:EC1.1.5.2

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IUBMB Comments

Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed 'propeller' structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
pqqgdh, quinoprotein glucose dehydrogenase, m-gdh, pqq-gdh, membrane-bound glucose dehydrogenase, pyrroloquinoline quinone-dependent glucose dehydrogenase, soluble glucose dehydrogenase, pqq-dependent glucose dehydrogenase, gdh-b, pqqgdh-b, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
show the reaction diagram