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Disease on EC 1.1.1.8 - glycerol-3-phosphate dehydrogenase (NAD+)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Atherosclerosis
[Structure of cytoplasmic glycerol-3-phosphate dehydrogenase in experimental atherosclerosis in rabbits]
beta-Thalassemia
Glycerol-3-phosphate dehydrogenase activity in the red cells of patients with thalassemia.
Breast Neoplasms
Comparative Proteome Analysis of Breast Cancer Tissues Highlights the Importance of Glycerol-3-phosphate Dehydrogenase 1 and Monoacylglycerol Lipase in Breast Cancer Metabolism.
Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer.
Carcinoma, Ehrlich Tumor
Changes in enzyme pattern of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content.
Carcinoma, Hepatocellular
Proportional activities of glycerol kinase and glycerol 3-phosphate dehydrogenase in rat hepatomas.
Chagas Disease
Differential tissue and flight developmental expression of glycerol-3-phosphate dehydrogenase isozymes in the Chagas disease vector Triatoma infestans.
Cholestasis, Intrahepatic
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
Citrullinemia
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
Dehydration
Cell wall involvement in the glycerol response to high osmolarity in the halotolerant yeast Debaryomyces hansenii.
Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.
Diabetes Mellitus
Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.
Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene.
Diabetes Mellitus, Experimental
Adaptive changes of glycerol 3-phosphate dehydrogenase level in rat skin: effects of starvation, alloxan diabetes and insulin.
Diabetes Mellitus, Type 2
Detection of variants in the mitochondrial glycerophosphate dehydrogenase gene in Japanese NIDDM patients.
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.
Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.
Diabetic Nephropathies
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Fatty Liver
Some lipogenic enzyme activities in rat livers in which an excessive fat accumulation occurred due to feeding low-level amino acid mixture diets.
The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice.
Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1.
glycerol-3-phosphate dehydrogenase (nad+) deficiency
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Expanding the molecular diversity and phenotypic spectrum of glycerol 3-phosphate dehydrogenase 1 deficiency.
Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise.
Glycerol-3-phosphate dehydrogenase 1 deficiency induces compensatory amino acid metabolism during fasting in mice.
mGPDH Deficiency leads to melanoma metastasis via induced NRF2.
Mitochondrial glycerol 3-phosphate dehydrogenase deficiency aggravates hepatic triglyceride accumulation and steatosis.
Successful fenofibrate therapy for severe and persistent hypertriglyceridemia in a boy with cirrhosis and glycerol-3-phosphate dehydrogenase 1 deficiency.
Head and Neck Neoplasms
[The cytochemical determination of alpha-glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheral blood lymphocytes of patients with hepatobiliary system pathology]
Hepatitis
[The cytochemical determination of alpha-glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheral blood lymphocytes of patients with hepatobiliary system pathology]
Hyperthyroidism
Thyroxine and tri-iodothyronine differently affect uncoupling protein-1 content and antioxidant enzyme activities in rat interscapular brown adipose tissue.
Hypertriglyceridemia
A novel homozygous mutation in the glycerol-3-phosphate dehydrogenase 1 gene in a Chinese patient with transient infantile hypertriglyceridemia: a case report.
Successful fenofibrate therapy for severe and persistent hypertriglyceridemia in a boy with cirrhosis and glycerol-3-phosphate dehydrogenase 1 deficiency.
Transient infantile hypertriglyceridemia with jaundice: A case report.
Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1.
Hypoglycemia
Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: Role of metabolic reprogramming in counterregulatory failure.
Infections
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Insulinoma
Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.
Intellectual Disability
Haploinsufficiency of the GPD2 gene in a patient with nonsyndromic mental retardation.
Liver Diseases
Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis.
Liver Neoplasms, Experimental
Proportional activities of glycerol kinase and glycerol 3-phosphate dehydrogenase in rat hepatomas.
Melanoma
Metabolic characterization of three hamster melanoma variants.
mGPDH Deficiency leads to melanoma metastasis via induced NRF2.
Melanoma, Amelanotic
Metabolic characterization of three hamster melanoma variants.
Metabolism, Inborn Errors
Expanding the molecular diversity and phenotypic spectrum of glycerol 3-phosphate dehydrogenase 1 deficiency.
Neoplasm Metastasis
mGPDH Deficiency leads to melanoma metastasis via induced NRF2.
Neoplasms
Changes in enzyme pattern of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content.
GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate.
Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer.
Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.
Metabolic characterization of three hamster melanoma variants.
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
mGPDH Deficiency leads to melanoma metastasis via induced NRF2.
The reversible expression of an adult isozyme locus, Gdc-1, in tumors of the mouse.
Non-alcoholic Fatty Liver Disease
Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis.
Obesity
Association Between Cytosolic Glycerol 3-Phosphate Dehydrogenase Gene Expression in Human Subcutaneous Adipose Tissue and BMI.
Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans.
Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration.
Prostatic Neoplasms
High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines.
Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.
Role of Mitochondrial Glycerol-3-Phosphate Dehydrogenase in Metabolic Adaptations of Prostate Cancer.
Proteinuria
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Seizures
Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia.
Sleep Apnea, Obstructive
The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene.
Starvation
Adaptive changes of glycerol 3-phosphate dehydrogenase level in rat skin: effects of starvation, alloxan diabetes and insulin.
Role of glycerol 3-phosphate dehydrogenase in glyceride metabolism. Effect of diet on enzyme activities in chicken liver.
The effect of iron limitation on glycerol production and expression of the isogenes for NAD(+)-dependent glycerol 3-phosphate dehydrogenase in Saccharomyces cerevisiae.
Thymoma
Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract.
Thyroid Neoplasms
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Urinary Bladder Neoplasms
Increased activity of glycerol 3-phosphate dehydrogenase and other lipogenic enzymes in human bladder cancer.