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Information on EC 1.1.1.66 - omega-hydroxydecanoate dehydrogenase for references in articles please use BRENDA:EC1.1.1.66
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EC Tree
IUBMB Comments Also acts, more slowly, on 9-hydroxynonanoate and 11-hydroxyundecanoate.
The enzyme appears in viruses and cellular organisms
Synonyms
dehydrogenase, omega-hydroxydecanoate,
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dehydrogenase, omega-hydroxydecanoate
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10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH + H+
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10-hydroxydecanoate:NAD+ 10-oxidoreductase
Also acts, more slowly, on 9-hydroxynonanoate and 11-hydroxyundecanoate.
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10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
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10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
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10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
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10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
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10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
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10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
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best substrate
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r
11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
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11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
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11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
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11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
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11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
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oxidation at 89% the rate of 10-hydroxydecanoic acid
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9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
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9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
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9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
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9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
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9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
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oxidation at 51% the rate of 10-hydroxydecanoic acid
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C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
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C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
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C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
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additional information
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C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
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additional information
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C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
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NAD+
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cannot be replaced by NADP+
NAD+
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cannot be replaced by NADP+
NAD+
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cannot be replaced by NADP+
NAD+
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cannot be replaced by NADP+
NAD+
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cannot be replaced by NADP+
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0.125
10-Hydroxydecanoate
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0.08
11-Hydroxyundecanoate
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40
9-Hydroxynonanoate
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additional information
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223, units defined as change in optical density at 340 nm of 0.001/min
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9 - 11
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about half-maximal activity at pH 9.0 and 11.0
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37
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assay at
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ADH7_HUMAN
386
0
41481
Swiss-Prot
ADH7_MOUSE
374
0
39904
Swiss-Prot
ADH7_RAT
374
0
40105
Swiss-Prot
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4�C, crude extract stable for a week
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Mitz, M.A.; Heinrikson, R.L.
Omega-hydroxy fatty acid dehydrogenase
Biochim. Biophys. Acta
46
45-50
1961
Equus caballus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Sus scrofa
brenda
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1.1.1.66 omega-hydroxydecanoate dehydrogenase
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