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Information on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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IUBMB Comments
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
3 alpha-hydroxysteroid dehydrogenase, akr1c, hydroxyprostaglandin dehydrogenase, akr1c1-4, type i 3alpha-hsd, bile-acid binding protein, 3alpha-hydroxysteroid dehydrogenase type 3, 3alpha-oxidoreductase, 3alpha-or, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+
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