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Information on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.1.1.49

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IUBMB Comments

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
g6pd, glucose-6-phosphate dehydrogenase, g6pdh, g-6-pd, glucose 6-phosphate dehydrogenase, g-6-pdh, g-6pd, zwf-1, glucose-6-phosphate 1-dehydrogenase, glc6pdh, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-phosphoglucose dehydrogenase
-
-
-
-
D-glucose 6-phosphate dehydrogenase
-
-
-
-
Entner-Doudoroff enzyme
-
-
-
-
G6PD
-
-
-
-
G6PD1
-
-
-
-
G6PD2
-
-
-
-
G6PD3
-
-
-
-
G6PD4
-
-
-
-
G6PD5
-
-
-
-
G6PD6
-
-
-
-
G6PDH1
-
-
-
-
G6PDH2
-
-
-
-
G6PDH3
-
-
-
-
G6PDH4
-
-
-
-
G6PDH5
-
-
-
-
G6PDH6
-
-
-
-
glucose 6-phosphate dehydrogenase (NADP)
-
-
-
-
glucose-6-phosphate 1-dehydrogenase
-
-
-
-
glucose-6-phosphate dehydrogenase
NADP-dependent glucose 6-phophate dehydrogenase
-
-
-
-
NADP-glucose-6-phosphate dehydrogenase
-
-
-
-
VEG11
-
-
-
-
Vegetative protein 11
-
-
-
-
Zwischenferment
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
cytosolic NADPH production (yeast), Entner-Doudoroff pathway I, formaldehyde oxidation I, heterolactic fermentation, pentose phosphate pathway (oxidative branch) I, superpathway of glycolysis and the Entner-Doudoroff pathway
SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:NADP+ 1-oxidoreductase
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
CAS REGISTRY NUMBER
COMMENTARY hide
9001-40-5
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH + H+
show the reaction diagram
-
Substrates: -
Products: -
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.045
-
cells grown on a phosphate-deficient medium TRP
0.09
-
cells grown on a phosphate-sufficient minimal medium M9
top print hide Go to Organism Search
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
soil-isolate
-
-
Manually annotated by BRENDA team
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A069PXM7_PSEAI
488
0
54591
TrEMBL
-
A0A071LAZ7_PSEAI
489
0
55592
TrEMBL
-
A0A241XTY1_PSEAI
489
0
55566
TrEMBL
-
A0A2I2CK03_PSEAI
489
0
55620
TrEMBL
-
A0A509J8T6_PSEAI
488
0
54621
TrEMBL
other Location (Reliability: 2)
A0A643J2S2_PSEAI
488
0
54595
TrEMBL
-
A0A6A9K4K2_PSEAI
488
0
54665
TrEMBL
Mitochondrion (Reliability: 2)
A0A7M3A3H5_PSEAI
489
0
55549
TrEMBL
other Location (Reliability: 3)
A0A9P1VWP7_PSEAI
489
0
55606
TrEMBL
other Location (Reliability: 2)
A0ABD7KAF9_PSEAI
488
0
54653
TrEMBL
-
A0ABD7K3C3_PSEAI
489
0
55582
TrEMBL
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Buch, A.; Archana, G.; Naresh Kumar, G.
Metabolic channeling of glucose towards gluconate in phosphate-solubilizing Pseudomonas aeruginosa P4 under phosphorus deficiency
Res. Microbiol.
159
635-642
2008
Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas aeruginosa P4
Manually annotated by BRENDA team