Information on EC 1.1.1.442 - 20beta-hydroxysteroid dehydrogenase

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD⁺ or NADP⁺ as acceptor 1.1.1.442 20beta-hydroxysteroid dehydrogenase

IUBMB Comments

The enzyme, characterized from several gut bacteria, is specific for NADH and is much more active in the reductive direction. cf. the eukaryotic enzyme EC 1.1.1.53, 3α(or 20β)-hydroxysteroid dehydrogenase.

The enzyme appears in viruses and cellular organisms

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20beta-dihydrocortisol + NAD+ = cortisol + NADH + H+

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20beta-dihydrocortisol:NAD+ 20-oxidoreductase

The enzyme, characterized from several gut bacteria, is specific for NADH and is much more active in the reductive direction. cf. the eukaryotic enzyme EC 1.1.1.53, 3alpha(or 20beta)-hydroxysteroid dehydrogenase.

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