The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs.
The expected taxonomic range for this enzyme is: Catharanthus roseus
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SYSTEMATIC NAME
IUBMB Comments
stemmadenine:NADP+ 17-oxidoreductase
The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs.
Qu, Y.; Easson, M.; Simionescu, R.; Hajicek, J.; Thamm, A.; Salim, V.; De Luca, V.
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine
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