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IUBMB Comments The enzyme, characterized from the mold Aspergillus fumigatus , participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain.
Synonyms af490 , Fma-KR,
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af490
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Fma-KR
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fumagillol + NADP+ = 5-dehydrofumagillol + NADPH + H+
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fumagillol:NADP+ 5-oxidoreductase
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain.
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5-dehydro-6-demethoxyfumagillol + NADPH + H+
6-demethoxyfumagillol + NADP+
5-dehydrocordycol + NADPH + H+
cordycol + NADP+
5-dehydrofumagillol + NADPH + H+
fumagillol + NADP+
5-dehydro-6-demethoxyfumagillol + NADPH + H+
6-demethoxyfumagillol + NADP+
Substrates: -
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5-dehydro-6-demethoxyfumagillol + NADPH + H+
6-demethoxyfumagillol + NADP+
Substrates: -
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5-dehydrocordycol + NADPH + H+
cordycol + NADP+
Substrates: -
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5-dehydrocordycol + NADPH + H+
cordycol + NADP+
Substrates: -
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5-dehydrofumagillol + NADPH + H+
fumagillol + NADP+
Substrates: -
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5-dehydrofumagillol + NADPH + H+
fumagillol + NADP+
Substrates: -
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
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FMAH_ASPFU
Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
1017
0
110955
Swiss-Prot
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x * 110000, SDS-PAGE
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x * 110000, SDS-PAGE
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Ni-NTA agarose resin column chromatography
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expressed in Saccharomyces cerevisiae strain BJ5464-NpgA
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Lin, H.; Tsunematsu, Y.; Dhingra, S.; Xu, W.; Fukutomi, M.; Chooi, Y.; Cane, D.; Calvo, A.; Watanabe, K.; Tang, Y.
Generation of complexity in fungal terpene biosynthesis Discovery of a multifunctional cytochrome P450 in the fumagillin pathway
J. Am. Chem. Soc.
136
4426-4436
2014
Aspergillus fumigatus (Q4WAZ4), Aspergillus fumigatus CEA17akuBKU80 (Q4WAZ4)
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