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Information on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.1.1.42

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IUBMB Comments

Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NAD+ but much more slowly [6,7].

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+
+
=
+
+
+

Synonyms
isocitrate dehydrogenase 1, nadp-isocitrate dehydrogenase, nadp-dependent isocitrate dehydrogenase, isocitrate dehydrogenase-1, nadp-icdh, nadp-idh, nadp+-dependent isocitrate dehydrogenase, nadp-linked isocitrate dehydrogenase, nadp-specific isocitrate dehydrogenase, nadp+-specific isocitrate dehydrogenase, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CtIDP1
-
-
-
-
CtIDP2
-
-
-
-
IDH
-
-
-
-
IDP
-
-
-
-
isocitrate dehydrogenase (NADP)
-
-
-
-
isocitrate dehydrogenase (NADP-dependent)
-
-
-
-
isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate)
-
-
-
-
NADP isocitric dehydrogenase
-
-
-
-
NADP+-linked isocitrate dehydrogenase
-
-
-
-
NADP+-specific ICDH
-
-
-
-
NADP-dependent isocitrate dehydrogenase
-
-
-
-
NADP-dependent isocitric dehydrogenase
-
-
-
-
NADP-linked isocitrate dehydrogenase
-
-
-
-
NADP-specific isocitrate dehydrogenase
-
-
-
-
oxalosuccinate decarboxylase
-
-
-
-
oxalsuccinic decarboxylase
-
-
-
-
PS-NADP-IDH
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidative decarboxylation
-
-
-
-
redox reaction
-
-
-
-
reductive carboxylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
cytosolic NADPH production (yeast), ethene biosynthesis V (engineered), methylaspartate cycle, mixed acid fermentation, nitrogen remobilization from senescing leaves, partial TCA cycle (obligate autotrophs), reductive TCA cycle I, TCA cycle I (prokaryotic), TCA cycle IV (2-oxoglutarate decarboxylase), TCA cycle V (2-oxoglutarate synthase), TCA cycle VI (Helicobacter), TCA cycle VII (acetate-producers)
SYSTEMATIC NAME
IUBMB Comments
isocitrate:NADP+ oxidoreductase (decarboxylating)
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [6]. The enzyme from some species can also use NAD+ but much more slowly [6,7].
CAS REGISTRY NUMBER
COMMENTARY hide
9028-48-2
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A069QAS5_PSEAI
418
0
45577
TrEMBL
-
A0A0C7CY91_PSEAI
741
0
81636
TrEMBL
-
A0A0F7QRI5_PSEAI
741
0
81622
TrEMBL
Mitochondrion (Reliability: 5)
A0A367M2C3_PSEAI
294
0
32653
TrEMBL
-
A0A367M880_PSEAI
132
0
13911
TrEMBL
-
A0A367MCY4_PSEAI
615
0
68049
TrEMBL
-
A0A3M5DBF8_PSEAI
741
0
81650
TrEMBL
-
A0A5E5R9K3_PSEAI
741
0
81637
TrEMBL
-
A0A643EK55_PSEAI
741
0
81623
TrEMBL
-
A0A643IS82_PSEAI
741
0
81596
TrEMBL
-
A0A6A9JKV1_PSEAI
741
0
81664
TrEMBL
-
A0A9P1R9W6_PSEAI
418
0
45519
TrEMBL
other Location (Reliability: 4)
A0AAQ3LUK4_PSEAI
741
0
81622
TrEMBL
Secretory Pathway (Reliability: 3)
A0ABD7K2Z8_PSEAI
418
0
45605
TrEMBL
other Location (Reliability: 4)
A0ABD7K303_PSEAI
741
0
81664
TrEMBL
-
PDB
SCOP
CATH
UNIPROT
ORGANISM