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EC Tree
IUBMB Comments The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming).
The enzyme appears in viruses and cellular organisms
Synonyms
isopyridoxal dehydrogenase,
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isopyridoxal dehydrogenase
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isopyridoxal + NAD+ = 5-pyridoxolactone + NADH + H+
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isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming)
The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming).
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isopyridoxal + NAD+
5-pyridoxolactone + NADH + H+
isopyridoxal + NAD+
5-pyridoxolactone + NADH + H+
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the enzyme participates in the degradation of pyridoxine
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isopyridoxal + NAD+
5-pyridoxolactone + NADH + H+
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the enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming)
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?
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isopyridoxal + NAD+
5-pyridoxolactone + NADH + H+
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the enzyme participates in the degradation of pyridoxine
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NAD+
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no activity with NADP+ or thionicotinamide adenine dinucleotide
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4-deoxyisopyridoxal
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competitive
5-pyridoxic acid
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competitive
DTNB
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0.005 mM, 50% loss of activity after 1 h
HgCl2
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0.02 mM, 67% loss of activity after 1 h
N-ethylmaleimide
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2.5 mM, 71% loss of activity after 1 h
PCMB
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0.005 mM, 75% loss of activity after 1 h
Thionicotinamide adenine dinucleotide
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noncompetitive
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0.04
Isopyridoxal
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pH 8.0, 25°C
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10
Isopyridoxal
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pH 8.0, 25°C
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0.00065
4-deoxyisopyridoxal
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pH 8.0, 25°C
0.7
5-pyridoxic acid
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pH 8.0, 25°C
0.13
Thionicotinamide adenine dinucleotide
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pH 8.0, 25°C
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brenda
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metabolism
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the enzyme participates in the degradation of pyridoxine
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homotetramer
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4 * 60000, SDS-PAGE
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the enzyme is induced in response to growth of the organisms on pyridoxine
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Lee, Y.; Nelson, M.; Snell, E.
Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase
J. Biol. Chem.
261
15106-15111
1986
Arthrobacter sp. Cr-7
brenda
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1.1.1.416 isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
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