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Information on EC 1.1.1.411 - L-threonate 2-dehydrogenase
for references in articles please use BRENDA:EC1.1.1.411
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.411 L-threonate 2-dehydrogenase
IUBMB Comments
The enzyme, characterized from bacteria, is involved in L-threonate catabolism.
The enzyme appears in viruses and cellular organisms
showSynonyms
L-threonate dehydrogenase, L-threonic acid dehydrogenase, ltnD, ThrDH, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
L-threonate dehydrogenase
L-threonic acid dehydrogenase
ltnD
ThrDH
ltnD
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-threonate + NAD+ = 2-dehydro-L-erythronate + NADH + H+
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
L-threonate degradation
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SYSTEMATIC NAME
IUBMB Comments
L-threonate:NAD+ 2-oxidoreductase
The enzyme, characterized from bacteria, is involved in L-threonate catabolism.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-xylonate + NAD+
? + NADH + H+
Substrates: -
Products: -
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?
L-idonate + NAD+
L-sorbosonic acid + NADH + H+
Substrates: -
Products: -
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?
L-idonate + NAD+
L-sorbosonic acid + NADH + H+
Agrobacterium tumefaciens ATCC BAA-868
Substrates: -
Products: -
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?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
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?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Agrobacterium tumefaciens ATCC BAA-868
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: specifically oxidizes L-threonic acid
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: specifically oxidizes L-threonic acid
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Agrobacterium tumefaciens ATCC BAA-868
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). LTND_CUPNH
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
297
0
30439
Swiss-Prot
-
LTND_ECOL6
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
302
0
30706
Swiss-Prot
-
LTND_HAEIN
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
301
1
31035
Swiss-Prot
-
LTND_PECAS
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
304
1
31629
Swiss-Prot
-
A0A6J5GVY8_9BURK
296
0
29994
TrEMBL
-
A0A6A7SG55_9ZZZZ
307
0
31413
TrEMBL
other Location (Reliability: 4)
B1G017_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
296
0
30138
TrEMBL
-
A0A6J5A2T4_9BURK
302
0
30538
TrEMBL
-
A0A6J5KD25_9BURK
302
0
30600
TrEMBL
-
B9J8U1_AGRRK
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
294
0
29972
TrEMBL
-
B9JKN9_AGRRK
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
322
0
33254
TrEMBL
-
Q1QSN6_CHRSD
Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)
310
1
32144
TrEMBL
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
Cupriavidus necator (Q0KBC7), Cupriavidus necator DSM 428 (Q0KBC7), Pectobacterium atrosepticum (Q6CZ26), Pectobacterium atrosepticum ATCC BAA-672 (Q6CZ26)
brenda
Zhang, C.F.; Liu, Y.P.; Wu, X.X.; Zhang, X.S.; Huang, H.
Substrate diversity of L-threonic acid dehydrogenase homologs
Biochemistry (Moscow)
85
463-471
2020
Agrobacterium tumefaciens (B9J8U1), Agrobacterium tumefaciens (B9JKN9), Agrobacterium tumefaciens ATCC BAA-868 (B9J8U1), Agrobacterium tumefaciens ATCC BAA-868 (B9JKN9), Chromohalobacter salexigens (Q1QSN6), Chromohalobacter salexigens ATCC BAA-138 (Q1QSN6), Cupriavidus necator (Q0KBC7), Cupriavidus necator ATCC 17699 (Q0KBC7)
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.411)
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Release 2023.1 (January 2023)
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