Information on EC 1.1.1.40 - malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.1.1.40

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD⁺ or NADP⁺ as acceptor 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

IUBMB Comments

The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP⁺ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating).

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

1.1.1.40
chloroplast
co2
carboxylase
phosphoenolpyruvate
maize
bundle
sheath
glucose-6-phosphate
mesophyll
carboxykinase
thioredoxins
dikinase
chlorophyll
grass
rubisco
photosystems
sorghum
nad-malic
6-phosphogluconate
lipogenesis
lipogenic
flaveria
fructose-1,6-bisphosphatase
orthophosphate
ribulose-1,5-bisphosphate
kranz
nadp-isocitrate
pck
crassulacean
photorespiration
nadph-generating
4.1.3.8
calvin
trinervia
phosphoribulokinase
non-photosynthetic
ferredoxin-thioredoxin
c4-like
bundle-sheath
photorespiratory
6.4.1.2
bidentis
crystallinum
3.1.3.11
4.1.1.31
fbpase
water-use
panicum
mesembryanthemum
nadp-icdh
analysis
biotechnology
medicine

Reaction Schemes

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oxaloacetate

pyruvate

CO2

Synonyms
nadp-me, nadp-malate dehydrogenase, nadp-malic enzyme, nadp-mdh, nadp-dependent malic enzyme, nadp-dependent malate dehydrogenase, nadp-me2, malic enzyme 1, nadp malic enzyme, nadp-me1, more

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Go to Synonym Search

L-malate:NADP oxidoreductase

malate dehydrogenase (decarboxylating, NADP)

malate dehydrogenase (NADP, decarboxylating)

malic enzyme

NADP+ dependent malic enzyme

NADP-linked decarboxylating malic enzyme

NADP-malic enzyme

NADP-ME

NADP-specific malate dehydrogenase

NADP-specific malic enzyme

pyruvic-malic carboxylase

TME

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decarboxylation

oxidation

redox reaction

reduction

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BRENDA

C4 and CAM-carbon fixation, gluconeogenesis, photosynthesis

KEGG

Carbon fixation in photosynthetic organisms, Microbial metabolism in diverse environments, Pyruvate metabolism

MetaCyc

C4 photosynthetic carbon assimilation cycle, NADP-ME type, C4 photosynthetic carbon assimilation cycle, PEPCK type, gluconeogenesis I

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(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)

The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating).

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Go to CAS Registry Number Search

9028-47-1

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Go to Substrate/Product Search

(S)-malate + NADP+

pyruvate + CO2 + NADPH