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Information on EC 1.1.1.392 - 3alpha-hydroxycholanate dehydrogenase (NADP+)

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IUBMB Comments
This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).
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The enzyme appears in viruses and cellular organisms
Synonyms
3alpha-HSDH, alpha-hydroxy-cholanate dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
lithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+
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